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64149

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By Targets:	Bcr-Abl (1) COX (3) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Herbicide (1) Interleukin Related (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) MicroRNA (8) Neurokinin Receptor (3) NF-κB (1) Reference Standards (1) Ser/Thr Protease (1) Src (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (4) Neurological Disease (4)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-B0335

Tolfenamic Acid 2 Publications Verification GEA 6414	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P3798

*Eglin c (41-49)*	Ser/Thr Protease	Others
Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with K_i values of 42 and 20 μM, respectively .

HY-B0335R

Tolfenamic Acid (Standard) GEA 6414 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-119044

KW-2149 KT-6149	Drug Derivative DNA Alkylator/Crosslinker	Cancer
KW-2149 (KT-6149) is a Mitomycin C (HY-13316) analogue activated by serum. KW-2149 can interact with DNA. KW-2149 exhibits antitumor activity. KW-2149 has pulmonary toxicity KW-2149 can be used for the research of cancer, such as leukemia .

HY-B0335S1

Tolfenamic acid-13C6 GEA 6414-¹³C₆	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-10363

AP 24149	Bcr-Abl Src	Cancer
AP 24149 is a potent Src-Abl dual inhibitor with IC₅₀ values of 9.1, 3.6 nM for Src and Abl, respectively .

HY-P1278A

*GR 64349* TFA**	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-RI03428A

*mmu-miR-6419* antagomir**	MicroRNA	Cancer
mmu-miR-6419 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6419 antagomir mmu-miR-6419 antagomir

HY-R03428

*mmu-miR-6419* mimic**	MicroRNA	Cancer
mmu-miR-6419 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-6419 mimic mmu-miR-6419 mimic

HY-RI03421

*mmu-miR-6414* inhibitor**	MicroRNA	Cancer
mmu-miR-6414 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-6414 inhibitor mmu-miR-6414 inhibitor

HY-R03421

*mmu-miR-6414* mimic**	MicroRNA	Cancer
mmu-miR-6414 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-6414 mimic mmu-miR-6414 mimic

HY-P1278B

*GR 64349* acetate**	Neurokinin Receptor	Neurological Disease Endocrinology
GR 64349 acetate is a selective neurokinin 2 (NK2) receptor agonist. GR 64349 acetate selectively activates the NK-2 receptor subtype. GR 64349 acetate activates tonic and rhythmic bladder contractions of the micturition reflex. GR 64349 acetate does not inhibit rhythmic bladder contraction activation induced by normal saline. GR 64349 acetate induces inward currents .

HY-W040802

AC-94149	Herbicide	Others
AC-94149 is a substituted nitro compound used as an intermediate in several herbicides .

HY-RI03421A

*mmu-miR-6414* antagomir**	MicroRNA	Cancer
mmu-miR-6414 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6414 antagomir mmu-miR-6414 antagomir

HY-R03421A

*mmu-miR-6414* agomir**	MicroRNA	Cancer
mmu-miR-6414 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6414 agomir mmu-miR-6414 agomir

HY-R03428A

*mmu-miR-6419* agomir**	MicroRNA	Cancer
mmu-miR-6419 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-6419 agomir mmu-miR-6419 agomir

HY-RI03428

*mmu-miR-6419* inhibitor**	MicroRNA	Cancer
mmu-miR-6419 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-6419 inhibitor mmu-miR-6419 inhibitor

Cat. No.	Product Name	Target	Research Area

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P3798

*Eglin c (41-49)*	Ser/Thr Protease	Others
Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with K_i values of 42 and 20 μM, respectively .

HY-P1278A

*GR 64349* TFA**	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1278B

*GR 64349* acetate**	Neurokinin Receptor	Neurological Disease Endocrinology
GR 64349 acetate is a selective neurokinin 2 (NK2) receptor agonist. GR 64349 acetate selectively activates the NK-2 receptor subtype. GR 64349 acetate activates tonic and rhythmic bladder contractions of the micturition reflex. GR 64349 acetate does not inhibit rhythmic bladder contraction activation induced by normal saline. GR 64349 acetate induces inward currents .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

Cat. No.	Product Name	Chemical Structure

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

Host:	Mouse (6) Rabbit (2)
Reactivity:	Human (8) Rat (4) Mouse (6) Monkey (2)
Application:	IHC-P (8) ICC/IF (3) IF-Tissue (4) IP (2) IHC-F (4) WB (8) FC (5) ELISA (3)
Isotype:	IgG (6) IgG1 (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84452

	B4GALNT1 Antibody (YA4149) GALGT; SPG26; GALNACT; GalNAc-T	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	B4GALNT1 Antibody (YA4149) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to B4GALNT1.

HY-P84452A

	B4GALNT1 Antibody (YA4149)(PBS only) GALGT; SPG26; GALNACT; GalNAc-T	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	B4GALNT1 Antibody (YA4149) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to B4GALNT1.

HY-P80829A

	Phospho-JAK2 (Tyr1007/1008) Antibody (YA6449) 1 Publications Verification JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Phospho-JAK2 (Tyr1007/1008) Antibody (YA6449) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-JAK2 (Tyr1007/1008).

HY-P86722

	Cytokeratin 17 Antibody (YA6414) 39.1; CK 17; Cytokeratin 17; Cytokeratin17; K17; Keratin 17; Keratin type I cytoskeletal 17; Keratin17; KRT 17; KRT17; KRT17 protein; PC; PC2; PCHC1; K1C17_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Cytokeratin 17 Antibody (YA6414) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 17.

HY-P86722A

	Cytokeratin 17 Antibody (YA6414)(PBS only) 39.1; CK 17; Cytokeratin 17; Cytokeratin17; K17; Keratin 17; Keratin type I cytoskeletal 17; Keratin17; KRT 17; KRT17; KRT17 protein; PC; PC2; PCHC1; K1C17_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Cytokeratin 17 Antibody (YA6414) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 17.

HY-P86457

	MEK-1/2 Antibody (YA6149) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK-1/2 Antibody (YA6149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK-1/2.

HY-P86727

	alpha smooth muscle Actin Antibody (YA6419) alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody (YA6419) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

HY-P86727A

	alpha smooth muscle Actin Antibody (YA6419)(PBS only) alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody (YA6419) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

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Cat. No.	Product Name		Classification

HY-RI03428A

*mmu-miR-6419* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-6419 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03428

*mmu-miR-6419* mimic**		MicroRNAs miRNA mimics
mmu-miR-6419 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03421

*mmu-miR-6414* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-6414 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R03421

*mmu-miR-6414* mimic**		MicroRNAs miRNA mimics
mmu-miR-6414 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03421A

*mmu-miR-6414* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-6414 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03421A

*mmu-miR-6414* agomir**		MicroRNAs miRNA agomirs
mmu-miR-6414 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03428A

*mmu-miR-6419* agomir**		MicroRNAs miRNA agomirs
mmu-miR-6419 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03428

*mmu-miR-6419* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-6419 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

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