118359-59-4
Chemical Structure
KW-2149
Synonym(s): KT-6149
- CAS No.: 118359-59-4
- Formula:C24H34N6O8S2
- Molecular Weight:598.69
IUPAC Name: N5-(2-((2-(((1aS,8S,8aR,8bS)-8-((carbamoyloxy)methyl)-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-6-yl)amino)ethyl)disulfanyl)ethyl)-L-glutamine
InChIKey: BIOSTZMAOGCGSC-CYUGEGSCSA-N
SMILES: CO[C@]12N(C[C@@]3([H])[C@]2([H])N3)C4=C(C(C(NCCSSCCNC(CC[C@H](N)C(O)=O)=O)=C(C4=O)C)=O)[C@H]1COC(N)=O
Biological Activity: KW-2149 (KT-6149) is a Mitomycin C (HY-13316) analogue activated by serum. KW-2149 can interact with DNA. KW-2149 exhibits antitumor activity. KW-2149 has pulmonary toxicity KW-2149 can be used for the research of cancer, such as leukemia[1][2].
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KW-2149 | KW-2149 (KT-6149) is a Mitomycin C (HY-13316) analogue activated by serum. KW-2149 can interact with DNA. KW-2149 exhibits antitumor activity. KW-2149 has pulmonary toxicity KW-2149 can be used for the research of cancer, such as leukemia. | |||||||||||||||||||||
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- [1]. Tsuruo T, et al. Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo. Cancer Chemother Pharmacol. 1990;27(2):89-93. [Content Brief]
- [2]. Schrijvers D, et al. KW-2149-induced pulmonary toxicity is not prevented by corticosteroids: a phase I and pharmacokinetic study. Anticancer Drugs. 1999 Aug;10(7):633-9 [Content Brief]
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