2. Gene
  3. Flot1 - flotillin 1 Gene

Flot1 - flotillin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Rareg

Gene ID: 64665 | Gene type: protein coding

About Flot1

Summary

Enables ionotropic glutamate receptor binding activity and protease binding activity. Predicted to be involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of cellular component organization; and protein localization to membrane. Predicted to act upstream of or within axonogenesis and regulation of Rho protein signal transduction. Located in caveola. Part of flotillin complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Apr 2022]

Flot1 Products(1)

mRNA Protein Name
NM_022701.2 NP_073192.2 flotillin-1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19298817 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
24612608 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19298817 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in caveola IDA
IDA: Inferred from direct assay
9858255 RGD
part of flotillin complex IDA
IDA: Inferred from direct assay
9858255 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20669324 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
12591123 RGD
is active in presynaptic active zone EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
23622064 RGD
is active in synapse IDA
IDA: Inferred from direct assay
20669324 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

flotillin-1

REG-2

reggie-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04982 FLOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flot1 NCBI NCBI:10211