LRTM2 - leucine rich repeats and transmembrane domains 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 654429

About LRTM2

This gene has 12 transcripts (splice variants), 1 gene allele, 274 orthologues and 25 paralogues. Restricted expression toward brain (RPKM 3.3).

Summary

Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRTM2 Products (3)

mRNA Protein Name
NM_001039029.3 NP_001034118.1 leucine-rich repeat and transmembrane domain-containing protein 2 precursor
NM_001163925.2 NP_001157397.1 leucine-rich repeat and transmembrane domain-containing protein 2 precursor
NM_001163926.2 NP_001157398.1 leucine-rich repeat and transmembrane domain-containing protein 2 precursor

LRTM2 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (39 - 67)

LRR_8

LRR_8: Leucine rich repeat (92 - 151)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and transmembrane domain-containing protein 2

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Axial
  • Axial Spondylometaphyseal Dysplasia

  • SMDAX

  • Axial Smd

  • Smd Axial

  • Smd, Axial

  • Spondylometaphyseal Dysplasia Axial Type

  • Dysplasia, Spondylometaphyseal, Axial

Preretinal Fibrosis
  • Cellophane Maculopathy

  • Macular Puckering Of Retina

  • Macular Retinal Puckering

  • Epiretinal Membrane

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris LRTM2 VGNC VGNC:42834
Felis catus LRTM2 VGNC VGNC:63319
Mus musculus LRTM2 MGD MGI:2141485
Bos taurus LRTM2 VGNC VGNC:31047
Rattus norvegicus LRTM2 RGD RGD:1587001