BNIP1 - BCL2 interacting protein 1 Gene

Homo sapiens

Also known as NIP1; SEC20; TRG-8

Gene ID: 662 | Gene type: protein coding

About BNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:173,144,531-173,164,387 (from NCBI)

This gene has 5 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 6.9) and 25 other tissues.

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

BNIP1 Products(4)

mRNA	Protein	Name
NM_001205.3	NP_001196.2	vesicle transport protein SEC20 isoform BNIP1
NM_013978.3	NP_053581.2	vesicle transport protein SEC20 isoform BNIP1-a
NM_013979.3	NP_053582.2	vesicle transport protein SEC20 isoform BNIP1-b
NM_013980.3	NP_053583.2	vesicle transport protein SEC20 isoform BNIP1-c

BNIP1 Protein Structure

Sec20

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

vesicle transport protein SEC20

BCL2/adenovirus E1B 19 kDa protein-interacting protein 1

Related Diseases

Diseases

Alias

Pyloric Stenosis

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome	DMC
Dmc Disease	Pseudo-Morquio Disease Type I
Dmc Syndrome

Fumarase Deficiency

Fumaric Aciduria	FMRD
Fumarate Hydratase Deficiency	Deficiency, Fumarase

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01562	BNIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BNIP1	MGD	MGI:109328
Canis familiaris	BNIP1	VGNC	VGNC:38492
Macaca mulatta	BNIP1	VGNC	VGNC:70271
Rattus norvegicus	BNIP1	RGD	RGD:620799
Felis catus	BNIP1	VGNC	VGNC:60143
Bos taurus	BNIP1	VGNC	VGNC:26531

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