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BNIP1 - BCL2 interacting protein 1 Gene

Also Known as NIP1; SEC20; TRG-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 662

About BNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:173,144,531-173,164,387 (from NCBI)

This gene has 5 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 6.9) and 25 other tissues.

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

BNIP1 Products (4)

mRNA	Protein	Name
NM_001205.3	NP_001196.2	vesicle transport protein SEC20 isoform BNIP1
NM_013978.3	NP_053581.2	vesicle transport protein SEC20 isoform BNIP1-a
NM_013979.3	NP_053582.2	vesicle transport protein SEC20 isoform BNIP1-b
NM_013980.3	NP_053583.2	vesicle transport protein SEC20 isoform BNIP1-c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	15272311	GOA
enables calcium-induced calcium release activity	IDA IDA: Inferred from direct assay	29222049	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7954800	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic process	IPI IPI: Inferred from physical interaction	7954800	GOA
involved in apoptotic process in response to mitochondrial fragmentation	IDA IDA: Inferred from direct assay	29222049	GOA
involved in endoplasmic reticulum membrane fusion	IMP IMP: Inferred from mutant phenotype	15272311	GOA
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	15272311	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	15272311	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	7954800	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15272311	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23896122	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	7954800	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	21931693	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	23896122	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	7954800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP1 Protein Structure

Sec20

0
100
200
228 a.a.

Protein Preferred Names	Protein Names
vesicle transport protein SEC20	BCL2/adenovirus E1B 19 kDa protein-interacting protein 1

BNIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BNIP1	Q12981	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	BNIP1	Q12981	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	BNIP1	Q12981	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	BNIP1	Q12981	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	BNIP1	Q12981	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	BNIP1	Q12981	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	BNIP1	Q12981	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	BNIP1	Q12981	VMA21	Homo sapiens	Q3ZAQ7	Validated Y2H	32296183
Intra	BNIP1	Q12981	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	BNIP1	Q12981	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	BNIP1	Q12981	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	BNIP1	Q12981	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	BNIP1	Q12981	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	BNIP1	Q12981	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	BNIP1	Q12981	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	BNIP1	Q12981	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	BNIP1	Q12981	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	BNIP1	Q12981	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	BNIP1	Q12981	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	BNIP1	Q12981	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	BNIP1	Q12981	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	BNIP1	Q12981	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	BNIP1	Q12981	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	BNIP1	Q12981	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	BNIP1	Q12981	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	BNIP1	Q12981	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	BNIP1	Q12981	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

BNIP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83584	BNIP1 Antibody (YA3329)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pyloric Stenosis
Smith-Mccort Dysplasia 1	Smith-Mccort Dysplasia SMC1 Smc Smith Mccort Dysplasia Smith-Mccort Dwarfism
Dyggve-Melchior-Clausen Disease	Dyggve-Melchior-Clausen Syndrome DMC Dmc Disease Pseudo-Morquio Disease Type I Dmc Syndrome
Fumarase Deficiency	Fumaric Aciduria FMRD Fumarate Hydratase Deficiency Deficiency, Fumarase
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01562	BNIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BNIP1	MGD	MGI:109328
Canis familiaris	BNIP1	VGNC	VGNC:38492
Macaca mulatta	BNIP1	VGNC	VGNC:70271
Rattus norvegicus	BNIP1	RGD	RGD:620799
Felis catus	BNIP1	VGNC	VGNC:60143
Bos taurus	BNIP1	VGNC	VGNC:26531
Others	BNIP1	NCBI