Ormdl3 - ORM1-like 3 (S. cerevisiae) Gene

Mus musculus

Also known as 2810011N17Rik

Gene ID: 66612 | Gene type: protein coding

About Ormdl3

Summary

Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and negative regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of SPOTS complex. Is expressed in lung. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Apr 2022]

Ormdl3 Products(1)

mRNA	Protein	Name
NM_025661.4	NP_079937.1	ORM1-like protein 3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of motor behavior	IGI IGI: Inferred from genetic interaction	31880535	MGI
acts upstream of myelination	IGI IGI: Inferred from genetic interaction	31880535	MGI
acts upstream of or within negative regulation of B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	28747345	MGI
acts upstream of or within negative regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	25691431	MGI
acts upstream of or within negative regulation of serine C-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	28275141	MGI
acts upstream of or within positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	28747345	MGI
acts upstream of regulation of ceramide biosynthetic process	IGI IGI: Inferred from genetic interaction	31880535	MGI
acts upstream of regulation of ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	31880535	MGI
acts upstream of regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	28275141	MGI
acts upstream of regulation of sphingolipid biosynthetic process	IGI IGI: Inferred from genetic interaction	31880535	MGI
acts upstream of regulation of sphingolipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	28275141	MGI
acts upstream of sphingomyelin biosynthetic process	IGI IGI: Inferred from genetic interaction	31880535	MGI
acts upstream of sphingomyelin biosynthetic process	IMP IMP: Inferred from mutant phenotype	31880535	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ORM1-like protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09833	ORMDL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ormdl3	NCBI	NCBI:94103

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