Derl1 - Der1-like domain family, member 1 Gene

Also Known as Derlin-1; 1110021N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67819

Summary

Predicted to enable several functions, including enzyme binding activity; misfolded protein binding activity; and signal recognition particle binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within cellular response to unfolded protein. Located in early endosome; endoplasmic reticulum quality control compartment; and late endosome. Is expressed in embryo; gut; pancreas epithelium; yolk sac; and yolk sac endoderm. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Apr 2022]

Derl1 Products (1)

mRNA Protein Name
NM_024207.4 NP_077169.1 derlin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22267725 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to unfolded protein IMP
IMP: Inferred from mutant phenotype
19509052 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26692333 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
19509052 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19509052 MGI
located in endoplasmic reticulum quality control compartment IDA
IDA: Inferred from direct assay
23233672 MGI
located in late endosome IDA
IDA: Inferred from direct assay
19509052 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

derlin-1

  • degradation in endoplasmic reticulum protein 1

  • der1-like protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03699 DERL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Derl1 NCBI NCBI:79139