Pcgf3 - polycomb group ring finger 3 Gene

Also Known as Rnf3; DONG1; RNF3A; E430039C14; 2310035N15Rik; D630042K08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69587

Summary

Predicted to enable metal ion binding activity. Involved in histone H2A-K119 monoubiquitination and inactivation of X chromosome by genetic imprinting. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Pcgf3 Products (3)

mRNA Protein Name
NM_001377000.1 NP_001363929.1 polycomb group RING finger protein 3 isoform 2
NM_001377001.1 NP_001363930.1 polycomb group RING finger protein 3 isoform 1
NM_172716.5 NP_766304.2 polycomb group RING finger protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H2AK119 ubiquitin ligase activity IMP
IMP: Inferred from mutant phenotype
28596365 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28596365 MGI
Biological Process GO Annotation Evidence References Source
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
28596365 MGI
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
28596365 MGI
colocalizes with X chromosome IDA
IDA: Inferred from direct assay
28596365 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb group RING finger protein 3

  • RING finger protein 3A

  • ring finger protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10147 PCGF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcgf3 NCBI NCBI:10336