SPAG16 - sperm associated antigen 16 Gene

Homo sapiens

Also known as PF20; WDR29

Gene ID: 79582 | Gene type: protein coding

About SPAG16

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:213,284,464-214,410,501 (from NCBI)

This gene has 11 transcripts (splice variants) and 245 orthologues. Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues.

Summary

Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]

SPAG16 Products(2)

mRNA	Protein	Name
NM_001025436.3	NP_001020607.1	sperm-associated antigen 16 protein isoform 2
NM_024532.5	NP_078808.3	sperm-associated antigen 16 protein isoform 1

SPAG16 Protein Structure

WD40

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

sperm-associated antigen 16 protein

WD repeat domain 29

Related Diseases

Diseases

Alias

Pulmonary Subvalvular Stenosis

Pulmonary Infundibular Stenosis	Congenital Infundibular Stenosis
Infundibular Pulmonic Stenosis	Infundibular Pulmonic Stenosis, Congenital
Subvalvular Pulmonic Stenosis

Brain Small Vessel Disease 2

Porencephaly 2	BSVD2
Gould Syndrome 2	Porencephaly 2, Formerly
Poren2, Formerly	Poren2

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13621	SPAG16 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SPAG16	VGNC	VGNC:80363
Macaca mulatta	SPAG16	VGNC	VGNC:77977
Mus musculus	SPAG16	MGD	MGI:1913972
Rattus norvegicus	SPAG16	RGD	RGD:1565062

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