SPAG16 - sperm associated antigen 16 Gene

Also Known as PF20; WDR29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79582

About SPAG16

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:213,284,464-214,410,501 (from NCBI)

This gene has 11 transcripts (splice variants) and 245 orthologues. Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues.

Summary

Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]

SPAG16 Products (2)

mRNA Protein Name
NM_001025436.3 NP_001020607.1 sperm-associated antigen 16 protein isoform 2
NM_024532.5 NP_078808.3 sperm-associated antigen 16 protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in axoneme assembly IMP
IMP: Inferred from mutant phenotype
17699735 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG16 Protein Structure

WD40

WD40: WD domain, G-beta repeat (343 - 378)

WD40

WD40: WD domain, G-beta repeat (387 - 422)

WD40

WD40: WD domain, G-beta repeat (426 - 464)

WD40

WD40: WD domain, G-beta repeat (470 - 506)

WD40

WD40: WD domain, G-beta repeat (511 - 548)

WD40

WD40: WD domain, G-beta repeat (596 - 631)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 631 a.a.
Protein Preferred Names Protein Names

sperm-associated antigen 16 protein

  • WD repeat domain 29

Related Diseases

Diseases Alias
Pulmonary Subvalvular Stenosis

  • Pulmonary Infundibular Stenosis

  • Congenital Infundibular Stenosis

  • Infundibular Pulmonic Stenosis

  • Infundibular Pulmonic Stenosis, Congenital

  • Subvalvular Pulmonic Stenosis
Brain Small Vessel Disease 2

  • Porencephaly 2

  • BSVD2

  • Gould Syndrome 2

  • Porencephaly 2, Formerly

  • Poren2, Formerly

  • Poren2
Mosaic Variegated Aneuploidy Syndrome

  • Warburton-Anyane-Yeboa Syndrome

  • Mva Syndrome

  • Mosaic Variegated Aneuplody Microcephaly Syndrome

  • Warburton Anyane Yeboa Syndrome
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13621 SPAG16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPAG16 VGNC VGNC:80363
Macaca mulatta SPAG16 VGNC VGNC:77977
Mus musculus SPAG16 MGD MGI:1913972
Rattus norvegicus SPAG16 RGD RGD:1565062
Others SPAG16 NCBI