PARP8 - poly(ADP-ribose) polymerase family member 8 Gene

Also Known as ARTD16; pART16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79668

About PARP8

This gene has 22 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 11.4), thyroid (RPKM 9.6) and 24 other tissues.

Summary

Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]

PARP8 Products (4)

mRNA Protein Name
NM_001178055.2 NP_001171526.1 protein mono-ADP-ribosyltransferase PARP8 isoform 1
NM_001178056.2 NP_001171527.1 protein mono-ADP-ribosyltransferase PARP8 isoform 2
NM_001331028.2 NP_001317957.1 protein mono-ADP-ribosyltransferase PARP8 isoform 3
NM_024615.4 NP_078891.2 protein mono-ADP-ribosyltransferase PARP8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP8

  • ADP-ribosyltransferase diphtheria toxin-like 16

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 24

  • DEE24

  • Epileptic Encephalopathy, Early Infantile, 24

  • Eiee24

  • Developmental And Epileptic Encephalopathy, 24

  • Early Infantile Epileptic Encephalopathy 24

  • Encephalopathy, Epileptic, Early Infantile, Type 24
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

  • Arc Syndrome

  • ARCS1

  • Arthrogryposis Renal Dysfunction Cholestasis Syndrome

  • Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

  • Arcs

  • Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

  • Arthrogryposis, Renal Dysfunction, And Cholestasis

  • Arthrogryposis-Renal Dysfunction-Cholestasis

  • Arthrogryposis - Renal Dysfunction - Cholestasis

  • Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

  • Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

  • Arthrogryposis Renal Dysfunction And Cholestasis 1

  • Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

  • Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

  • Kidney Failure

  • Renal Insufficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10070 PARP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PARP8 RGD RGD:1587384
Felis catus PARP8 VGNC VGNC:102281
Mus musculus PARP8 MGD MGI:1098713
Canis familiaris PARP8 VGNC VGNC:49024
Macaca mulatta PARP8 VGNC VGNC:84477
Others PARP8 NCBI