CFHR5 - complement factor H related 5 Gene

Also Known as FHR5; CFHL5; FHR-5; CFHR5D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81494

About CFHR5

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:196,975,034-197,009,678 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 39 paralogues and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 44.1).

Summary

This gene is a member of a small complement Factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a Complement Component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]

CFHR5 Products (1)

mRNA	Protein	Name
NM_030787.4	NP_110414.1	complement factor H-related protein 5 precursor

CFHR5 Protein Structure

Sushi

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569 a.a.

Protein Preferred Names	Protein Names
complement factor H-related protein 5	factor H-related protein 5

CFHR5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CFHR5	Q9BXR6	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	KCNK7	Homo sapiens	Q9Y2U2-2	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	KCNK7	Homo sapiens	Q9Y2U2-2	Validated Y2H	32296183
Intra	CFHR5	Q9BXR6	KCNK7	Homo sapiens	Q9Y2U2-2	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	CFHR1	Homo sapiens	Q03591	GMS	23728178
Intra	CFHR5	Q9BXR6	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	CFHR5	Q9BXR6	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	CFHR5	Q9BXR6	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	CFHR5	Q9BXR6	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	25910212
Intra	CFHR5	Q9BXR6	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	25910212
Intra	CFHR5	Q9BXR6	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	CREB3L1	Homo sapiens	Q96BA8	Y2H Bait-Prey Pool	25910212
Intra	CFHR5	Q9BXR6	PANX1	Homo sapiens	Q96RD7	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	PANX1	Homo sapiens	Q96RD7	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC4A1	Homo sapiens	P02730	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	SLC4A1	Homo sapiens	P02730	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	CFHR5	Q9BXR6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	CFHR5	Q9BXR6	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	CFHR5	Q9BXR6	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	CFHR5	Q9BXR6	EBAG9	Homo sapiens	O00559	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CFHR5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70102	CFHR5 Protein, Human (HEK293, His)	Q9BXR6 (E19-E569)	≥ 95%, as determined by reducing SDS-PAGE.

CFHR5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84771	CFHR5 Antibody (YA4468)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84771A	CFHR5 Antibody (YA4468)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
C3 Glomerulopathy 3	Cfhr5 Deficiency Nephropathy Due To Cfhr5 Deficiency C3G3 Cfhr5 Nephropathy CFHR5D
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
C3 Glomerulopathy	C3 Glomerulonephritis C3g Non-Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis Glomerulonephritis With Dominant C3 Ddd Ddd/Mpgnii Dense Deposit Disease Membranoproliferative Glomerulonephritis Type Ii Non-Ig-Mediated Mpgn Non-Ig-Mediated Membranoproliferative Glomerulonephritis Non-Immunoglobulin-Mediated Mpgn Membranoproliferative Glomerulonephritis, Type Ii
D-Minus Hemolytic Uremic Syndrome	Atypical Hus Atypical Hemolytic Uremic Syndrome Hus, Atypical Ahus
Glomerulonephritis	Bright'S Disease
Membranoproliferative Glomerulonephritis	Mesangiocapillary Glomerulonephritis Dense Deposit Disease Membranoproliferative Glomerulonephritis Type 2 Primary Membranoproliferative Glomerulonephritis Mesangiocapillary Glomerulonephritis, Type Ii Glomerulonephritis, Membranoproliferative Chronic Glomerulonephritis, Lobular Lobular Glomerulonephritis Ddd Glomerulonephritis Membranoproliferative Type 2 Mpgn 2 Membranoproliferative Glomerulonephritis Type Ii Mesangiocapillary Glomerulonephritis Type 2 Mpgn Primary Mpgn Glomerulonephritis Membranoproliferative Membranoproliferative Glomerulonephritis, Type Ii
Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome Haemolytic-Uraemic Syndrome Hus Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes Typical Haemolytic Uraemic Syndrome Gasser Syndrome Hus - [Haemolytic Uraemic Syndrome]
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations	MCPH2 Primary Autosomal Recessive Microcephaly 2 With Or Without Cortical Malformations Microcephaly, Primary Autosomal Recessive, 2
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Acute Poststreptococcal Glomerulonephritis	Post-Streptococcal Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Hematuria, Benign Familial	Benign Familial Hematuria BFH Thin Membrane Nephropathy Tmn Thin Basement Membrane Nephropathy Thin-Basement-Membrane Nephropathy Hematuria, Familial Benign Hematuria Benign Familial Hematuria, Benign, Familial Thin Basement Membrane Disease
Complement Deficiency	Complement Deficiency Disease Hereditary Complement Deficiency Diseases
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
X-Linked Alport Syndrome	Nephropathy And Deafness, X-Linked
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Kidney Cortex Necrosis	Renal Cortical Necrosis
Angioedema, Hereditary, 1	Hereditary Angioedema Type I Hereditary Angioneurotic Edema Hane C1 Esterase Inhibitor Deficiency Angioedema, Hereditary, 1 And 2 HAE1 Angioneurotic Edema, Hereditary Angioedema, Hereditary, Type I Hereditary Angioedema Type 2 Hae 2 Hae-Ii Hereditary Angioneurotic Edema Type 2 Angioedema, Hereditary HAE Angioedema, Hereditary, Types I And Ii Hereditary Angioedema, Type Ii Angioedema, Hereditary, Type 1 Angioedemas, Hereditary Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii
Autosomal Recessive Alport Syndrome	Alport Syndrome, Recessive Type Alport Syndrome, Autosomal Recessive Alport Syndrome Autosomal Recessive Alport Syndrome Recessive Type Nephropathy And Deafness
Methylmalonic Aciduria And Homocystinuria, Cblc Type	MAHCC Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic Methylmalonic Aciduria And Homocystinuria Type Cblc Cobalamin C Disease Methylmalonic Acidemia With Homocystinuria Cblc Methylmalonic Acidemia And Homocystinuria, Cblc Type Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive Cobalamin C Deficiency Methylmalonic Acidemia With Homocystinuria, Type Cblc Cblc Defect Cobalamin C Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc Methylmalonic Aciduria With Homocystinuria, Type Cblc Methylmalonic Acidemia And Homocystinuria Cblc Type Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive Aciduria, Methylmalonic, And Homocystinuria, Cblc Type Methylmalonic Acidemia With Homocystinuria
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Degeneration Of Macula And Posterior Pole	Degeneration Of Macula And Posterior Pole Of Retina Degeneration Of Macula Or Posterior Pole Macular Degeneration Nos Degenerative Disorder Of Macula Drusen Macular Degeneration Posterior Pole Macular Degeneration Of Eye Macular Eye Degeneration Macular Degeneration Of Retina, Unspecified Pseudohole Degeneration Of Macula Of Retina
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Autosomal Dominant Alport Syndrome	Alport Syndrome, Autosomal Dominant Alport Syndrome Dominant Type Renal Failure And Sensorineural Hearing Loss Alport Syndrome, Dominant Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02566	CFHR5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown