WDR54 - WD repeat domain 54 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84058

About WDR54

This gene has 12 transcripts (splice variants), 201 orthologues and 14 paralogues. Broad expression in testis (RPKM 18.8), lung (RPKM 6.6) and 23 other tissues.

Summary

Enables protein homodimerization activity. Involved in negative regulation of receptor internalization; regulation of MAPK cascade; and regulation of epidermal growth factor receptor signaling pathway. Located in vesicle. [provided by Alliance of Genome Resources, Apr 2022]

WDR54 Products (4)

mRNA Protein Name
NM_001320823.2 NP_001307752.1 WD repeat-containing protein 54 isoform a
NM_001320824.2 NP_001307753.1 WD repeat-containing protein 54 isoform b
NM_001320825.2 NP_001307754.1 WD repeat-containing protein 54 isoform c
NM_032118.4 NP_115494.1 WD repeat-containing protein 54 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
30458214 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
30458214 GOA
involved in regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
30458214 GOA
involved in regulation of epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
30458214 GOA
Cellular Component GO Annotation Evidence References Source
located in vesicle IDA
IDA: Inferred from direct assay
30458214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR54 Protein Structure

WD40

WD40: WD domain, G-beta repeat (247 - 280)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 54

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15786 WDR54 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WDR54 VGNC VGNC:36905
Rattus norvegicus WDR54 RGD RGD:1561494
Macaca mulatta WDR54 VGNC VGNC:79541
Canis familiaris WDR54 VGNC VGNC:48375
Mus musculus WDR54 MGD MGI:1922909
Felis catus WDR54 VGNC VGNC:67040
Others WDR54 NCBI