NSRP1 - nuclear speckle splicing regulatory protein 1 Gene

Also Known as CCDC55; NSrp70; HSPC095; NEDSSBA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84081

About NSRP1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,116,816-30,186,475 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 8.1) and 25 other tissues.

Summary

Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

NSRP1 Products (2)

mRNA Protein Name
NM_001261467.2 NP_001248396.1 nuclear speckle splicing regulatory protein 1 isoform 2
NM_032141.4 NP_115517.1 nuclear speckle splicing regulatory protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
21296756 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21296756 GOA
Biological Process GO Annotation Evidence References Source
involved in developmental process IMP
IMP: Inferred from mutant phenotype
21296756 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
21296756 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
21296756 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21296756 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
21296756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSRP1 Protein Structure

DUF2040

DUF2040: Coiled-coil domain-containing protein 55 (DUF2040) (57 - 180)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 558 a.a.
Protein Preferred Names Protein Names

nuclear speckle splicing regulatory protein 1

  • coiled-coil domain containing 55

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Spasticity, Seizures, And Brain Abnormalities

  • NEDSSBA
Spasticity
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09600 NSRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NSRP1 VGNC VGNC:99310
Canis familiaris NSRP1 VGNC VGNC:43989
Rattus norvegicus NSRP1 RGD RGD:1309863
Bos taurus NSRP1 VGNC VGNC:32284
Macaca mulatta NSRP1 VGNC VGNC:97797
Mus musculus NSRP1 MGD MGI:2144305
Others NSRP1 NCBI