BTAF1 - B-TFIID TATA-box binding protein associated factor 1 Gene

Also Known as MOT1; TAF172; TAFII170; TAF(II)170

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9044

About BTAF1

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,923,770-92,031,437 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 30 paralogues. Ubiquitous expression in skin (RPKM 23.9), lymph node (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with Other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]

BTAF1 Products (1)

mRNA Protein Name
NM_003972.3 NP_003963.1 TATA-binding protein-associated factor 172

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent activity, acting on DNA IDA
IDA: Inferred from direct assay
9488487 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
9488487 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9488487 GOA
acts upstream of or within negative regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
23361013 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTAF1 Protein Structure

DUF3535

DUF3535: Domain of unknown function (DUF3535) (586 - 1053)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (1269 - 1585)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1670 - 1744)

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  • 1500
  • 1849 a.a.
Protein Preferred Names Protein Names

TATA-binding protein-associated factor 172

  • ATP-dependent helicase BTAF1

Related Diseases

Diseases Alias
Splenic Manifestation Of Leukemia

  • Splenic Leukemia
Cockayne Syndrome B

  • Cockayne Syndrome Type 2

  • Cockayne Syndrome, Type B

  • Cockayne Syndrome Type Ii

  • CSB

  • Cockayne Syndrome 2

  • Cockayne Syndrome Type B

  • Ckn2

  • Cockayne Syndrome, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01651 BTAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BTAF1 RGD RGD:1564130
Canis familiaris BTAF1 VGNC VGNC:38544
Macaca mulatta BTAF1 VGNC VGNC:70336
Felis catus BTAF1 VGNC VGNC:60193
Bos taurus BTAF1 VGNC VGNC:55937
Mus musculus BTAF1 MGD MGI:2147538
Others BTAF1 NCBI