2. Gene
  3. BTAF1 - B-TFIID TATA-box binding protein associated factor 1 Gene

BTAF1 - B-TFIID TATA-box binding protein associated factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MOT1; TAF172; TAFII170; TAF(II)170

Gene ID: 9044 | Gene type: protein coding

About BTAF1

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,923,770-92,031,437 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 30 paralogues. Ubiquitous expression in skin (RPKM 23.9), lymph node (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]

BTAF1 Products(1)

mRNA Protein Name
NM_003972.3 NP_003963.1 TATA-binding protein-associated factor 172

BTAF1 Protein Structure

DUF3535

DUF3535: Domain of unknown function (DUF3535) (586 - 1053)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (1269 - 1585)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1670 - 1744)

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  • 1849 a.a.
Protein Preferred Names Protein Names

TATA-binding protein-associated factor 172

ATP-dependent helicase BTAF1

Related Diseases

Diseases Alias
Splenic Manifestation Of Leukemia

Splenic Leukemia
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01651 BTAF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BTAF1 RGD RGD:1564130
Canis familiaris BTAF1 VGNC VGNC:38544
Macaca mulatta BTAF1 VGNC VGNC:70336
Felis catus BTAF1 VGNC VGNC:60193
Bos taurus BTAF1 VGNC VGNC:55937
Mus musculus BTAF1 MGD MGI:2147538