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Cat. No.: HY-W725454

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Acetaminosalol

Acetaminosalol, a merged ester NSAID–APAP hybrid, is a metabolite of Benorylate (HY-107795) and a prodrug of Acetaminophen (HY-66005) and Aalicylic acid (HY-B0167). Acetaminosalol can be used for the research of acute rheumatism.

For research use only. We do not sell to patients.

CAS No.: 118-57-0
Formula: C₁₅H₁₃NO₄
Molecular Weight:271.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acetaminosalol Chemical Structure

CAS No.: 118-57-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	Inhibition	102.732 % Compound: ACETAMINOSALOL	Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	[PMID: 23571415]
CHO	Inhibition	103.085 % Compound: ACETAMINOSALOL	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	[PMID: 23571415]

In Vitro

Acetaminosalol (Compound 47) is a chemically stable prodrug that resists gastric juice hydrolysis, undergoes enzymatic hydrolysis in human plasma and rat liver homogenate to release active Aalicylic acid (HY-B0167) and Acetaminophen (HY-66005)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 118-57-0
Molecular Weight 271.27
Formula C₁₅H₁₃NO₄
SMILES

O=C(OC1=CC=C(C=C1)NC(=O)C)C=2C=CC=CC2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kouznetsov VV, et al. Exploring acetaminophen prodrugs and hybrids: a review. RSC Adv. 2024;14(14):9691-9715. Published 2024 Mar 22. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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