Cys-MC-GGFG-Dxd
Based on 1 Customer Validation
Cys-MC-GGFG-Dxd is a cysteine-modified, cleavable ADC drug-linker conjugate. Cys-MC-GGFG-Dxd consists of a maleimidocaproyl-glycine-glycine-L-phenylalanine-glycine (MC-GGFG) linker and an Exatecan (HY-13631) derivative (DXd) (HY-13631D) payload. Cys-MC-GGFG-Dxd can be further conjugated to anti-HER2 IgG1κ antibody for the synthesis of antibody-drug conjugates (ADC), such as the breast cancer-targeting ADC compound Fam-trastuzumab deruxtecan-nxki (Enhertu).
For research use only. We do not sell to patients.
- Purity: 99.01%
- CAS No.: 3025787-83-8
- Formula: C55H63FN10O15S
- Molecular Weight:1155.21
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
The ADC conjugate related to Cys-MC-GGFG-DXd can also be generated via enzymatic hydrolysis of ADC in human liver lysosomes, human liver S9 fractions and H358 non-small cell lung cancer cells. The proportions of mass spectrometry peak areas of Cys-MC-GGFG-DXd reach 8.11%, 35.06% and 40.01% at 48 h in human liver lysosomes, 72 h in human liver S9 fractions and 96 h in tumor cells, respectively, making it the metabolite with the highest abundance besides the parent DXd[2].
Hydrolysis analysis results of Cys-MC-GGFG-Dxd show that Dxd is mainly released inside cells and then penetrates the cell membrane to enter the incubation medium; this mechanism serves as the critical basis for the "bystander effect"[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 3025787-83-8
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Appearance Solid
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Molecular Weight 1155.21
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Formula C55H63FN10O15S
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Color Light yellow to yellow
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SMILES
O=C(CC(SC[C@H](N)C(O)=O)C1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C(CN5C6=CC7=C(COC([C@]7(O)CC)=O)C5=O)C6=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (43.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8656 mL | 4.3282 mL | 8.6564 mL | 21.6411 mL |
| 5 mM | 0.1731 mL | 0.8656 mL | 1.7313 mL | 4.3282 mL | |
| 10 mM | 0.0866 mL | 0.4328 mL | 0.8656 mL | 2.1641 mL | |
| 15 mM | 0.0577 mL | 0.2885 mL | 0.5771 mL | 1.4427 mL | |
| 20 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0821 mL | |
| 25 mM | 0.0346 mL | 0.1731 mL | 0.3463 mL | 0.8656 mL | |
| 30 mM | 0.0289 mL | 0.1443 mL | 0.2885 mL | 0.7214 mL | |
| 40 mM | 0.0216 mL | 0.1082 mL | 0.2164 mL | 0.5410 mL |
Cys-MC-GGFG-Dxd Related Classifications
HY-176415 Related Classifications
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