ALKBH5 - alkB homolog 5, RNA demethylase Gene

Also Known as ABH5; OFOXD; OFOXD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54890

About ALKBH5

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,183,828-18,209,954 (from NCBI)

This gene has 3 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 46.1), heart (RPKM 30.6) and 25 other tissues.

Summary

Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH5 Products (1)

mRNA Protein Name
NM_017758.4 NP_060228.3 RNA demethylase ALKBH5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
21264265 GOA
enables mRNA N6-methyladenosine dioxygenase activity IDA
IDA: Inferred from direct assay
23177736 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
37474102 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
34048572 GOA
involved in non-membrane-bounded organelle assembly IDA
IDA: Inferred from direct assay
37474102 GOA
acts upstream of or within regulation of mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
23177736 GOA
acts upstream of or within regulation of mRNA processing IMP
IMP: Inferred from mutant phenotype
23177736 GOA
involved in regulation of translation IDA
IDA: Inferred from direct assay
36944332 GOA
involved in response to hypoxia IDA
IDA: Inferred from direct assay
21264265 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
23177736 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21264265 GOA
is active in paraspeckles IDA
IDA: Inferred from direct assay
37474102 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH5 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (119 - 275)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

RNA demethylase ALKBH5

  • AlkB family member 5, RNA demethylase

ALKBH5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83693 ALKBH5 Antibody (YA3429) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Cervix Carcinoma

  • Cancer Of Cervix

  • Carcinoma Of Cervix

  • Carcinoma Cervix Uteri

  • Carcinoma Of The Cervix Uteri
Retinitis Pigmentosa 11

  • RP11

  • Retinitis Pigmentosa-11

  • Retinitis Pigmentosa, Type 11
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-155489 DDO-2728 98.64% Unkown
HY-165422 ALKBH5-IN-3 Inhibitor 99.63% Unkown
HY-172158 ALKBH5-IN-5 99.66% Unkown
HY-173020 W23-1006 97.15% Unkown
HY-W173146 ALKBH5-IN-4 98.82% Unkown
HY-149145 Ena15 ≥99.0% Unkown
HY-174979 Dac590 96.15% Unkown
HY-148933 ALKBH5-IN-2 Inhibitor / Unkown
HY-RS00606 ALKBH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170668 DDO-02267 Inhibitor / Unkown
HY-179266 FTO-IN-15 Inhibitor / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-N4031 Humantenine Chemical 98% Unkown
HY-RS16695 Alkbh5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23130 Alkbh5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ALKBH5 RGD RGD:1309496
Macaca mulatta ALKBH5 VGNC VGNC:103786
Bos taurus ALKBH5 VGNC VGNC:25836
Canis familiaris ALKBH5 VGNC VGNC:53262
Felis catus ALKBH5 VGNC VGNC:98758
Mus musculus ALKBH5 MGD MGI:2144489
Others ALKBH5 NCBI