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Cat. No.: HY-148933

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ALKBH5-IN-2

ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC₅₀ value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability.

For research use only. We do not sell to patients.

CAS No.: 1008951-10-7
Formula: C₉H₁₁N₃O₃
Molecular Weight:209.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ALKBH5-IN-2 Chemical Structure

CAS No.: 1008951-10-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC₅₀ value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]
HL-60	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]
K562	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]

In Vitro

ALKBH5-IN-2 (compound 6) (0-50µM; 48 h) inhibits cell viability with IC₅₀s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells
Concentration:

0-50 µM
Incubation Time:

48 h
Result:

Inhibited cell growth with IC₅₀s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively.

Chemical Information

CAS No. 1008951-10-7
Molecular Weight 209.20
Formula C₉H₁₁N₃O₃
SMILES

O=C1NNC(C(C1)NCC2=CC=CO2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Selberg S, et al. Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors. ACS Omega. 2021 May 14;6(20):13310-13320. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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