Adamantanine
Based on 1 Customer Validation
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 42381-05-5
- Formula: C11H17NO2
- Molecular Weight:195.26
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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3D Diverse Fragment Library
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats model[2]
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Dosage:500-1000 mg/kg
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Administration:i.p., single dose; p.o., single dose
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Result:Exhibited no toxicity.
Chemical Information
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CAS No. 42381-05-5
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Appearance Solid
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Molecular Weight 195.26
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Formula C11H17NO2
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Color Off-white to yellow
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SMILES
OC(C1([C@H]2C[C@H](C3)C[C@@H]1C[C@H]3C2)N)=O
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Synonyms
2-Aminoadamantane-2-carboxylic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Nagasawa HT, et al., Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem. 1975 Aug;18(8):826-30. [Content Brief]
[2]. Nagaswa HT, et al., 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16(7):823-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adamantanine Related Classifications
HY-121123 Related Classifications
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