(R)-SR-C-107
(R)-SR-C-107 is an orally available inhibitor of ENL (YEAST domain-containing protein) designed to target acute myeloid leukemia (AML). (R)-SR-C-107 targets ENL with IC50 and KD of 40 nM and 144 nM, respectively. (R)-SR-C-107 demonstrates in vivo efficacy in a xenograft mouse model of AML, with a tumor regression rate of 45% at a dose of 200 mg/kg (PO; QD).
For research use only. We do not sell to patients.
- Formula: C21H23N7O
- Molecular Weight:389.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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Molecular Weight 389.45
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Formula C21H23N7O
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SMILES
O=C(C1=CN2C(C=C1)=NN=C2)NC3=CC(NC(CN4[C@@H](C(C)C)CC4)=C5)=C5C=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-SR-C-107 Related Classifications
HY-169937 Related Classifications
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