1. Vitamin D Related
    Apoptosis
  2. VD/VDR
    Apoptosis
  3. Inecalcitol

Inecalcitol (Synonyms: TX 522)

Cat. No.: HY-32344 Purity: 98.11%
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Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist. Inecalcitol can induce cell apoptosis and has potent anticancer activities[3.

For research use only. We do not sell to patients.

Inecalcitol Chemical Structure

Inecalcitol Chemical Structure

CAS No. : 163217-09-2

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1 mg USD 650 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist. Inecalcitol can induce cell apoptosis and has potent anticancer activities[1][2][3.

In Vitro

Inecalcitol (0.1-10 nM; 48 hours) treatment of LNCaP cells resulted in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner. Inecalcitol (0.1-10 nM; 48 hours) also decreases ETV1 expression levels in a dose-dependent manner[1].
Inecalcitol (10-14 days) inhibits the growth of LNCaP and HL-60 cells with ED50 values of 4.0 nM and 0.28 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: LNCaP cells
Concentration: 0.1 nM, 1 nM, 10 nM
Incubation Time: 48 hours
Result: Resulted in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner.
In Vivo

Inecalcitol (1.3 mg/kg; i.p.; 3 times per week; for 42 days) inhibits androgen-responsive prostate cancer growth in vivo[1].
Pharmacokinetic studies show that plasma half-life of Inecalcitol (C57Bl/6J mice; 1.3 mg/kg; i.p.) is 18.3 minutes in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BNX nu/nu mice (8 weeks of age) injected with LNCaP cells[1]
Dosage: 1.3 mg/kg
Administration: i.p.; 3 times per week; for 42 days
Result: Inhibited androgen-responsive prostate cancer growth in vivo.
Molecular Weight

400.59

Formula

C₂₆H₄₀O₃

CAS No.
SMILES

O[[email protected]]1C[[email protected]](O)C/C(C1)=C/C=C2[[email protected]@]3([H])CC[[email protected]]([[email protected]](C)CC#CC(C)(O)C)[[email protected]@]3(C)CCC/2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

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Keywords:

InecalcitolTX 522TX522TX-522VD/VDRApoptosisVitamin DVitamin D receptorantiproliferativeETV1anticancerPim-1VDR,Inhibitorinhibitorinhibit

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