2. NF-κB
  3. NF-κB
  4. IR-Crizotinib

IR-Crizotinib is a NF-κB-inducing kinase (NIK) inhibitor that crosses the blood-brain barrier and fluorescently localizes intracranial glioblastoma (GBM) in mice (IC50=3.381 μM). IR-Crizotinib is conjugated from the near-infrared dye IR-786 and the NF-κB-inducing kinase (NIK) inhibitor Crizotinib. IR-Crizotinib can effectively inhibit the growth and invasion of glioma in vitro and in vivo and can be used in cancer research.

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IR-Crizotinib Chemical Structure

IR-Crizotinib Chemical Structure

CAS No. : 2387927-74-2

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IR-Crizotinib Related Antibodies

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Description

IR-Crizotinib is a NF-κB-inducing kinase (NIK) inhibitor that crosses the blood-brain barrier and fluorescently localizes intracranial glioblastoma (GBM) in mice (IC50=3.381 μM). IR-Crizotinib is conjugated from the near-infrared dye IR-786 and the NF-κB-inducing kinase (NIK) inhibitor Crizotinib. IR-Crizotinib can effectively inhibit the growth and invasion of glioma in vitro and in vivo and can be used in cancer research[1].

IC50 & Target

IC50: NF-κB-inducing kinase (3.381 μM)[1].
Molecular Weight

1024.87

Formula

C53H57Cl2FIN7O
CAS No.
SMILES

NC(C(O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C)=C2)=NC=C2C3=CN(N=C3)C4CCN(C5=C(/C=C/C6=[N+](C)C(C=CC=C7)=C7C6(C)C)CCC/C5=C\C=C8C(C)(C)C(C=CC=C9)=C9N/8C)CC4.[I-]
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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IR-Crizotinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-Crizotinib2387927-74-2NF-κBNuclear factor-κBNuclear factor-kappaBGBMcancertumorIR-786BT25U87293TU87- RFP-LUCBT25-RFP-LUCInhibitorinhibitorinhibit

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IR-Crizotinib
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