2,4-Dibromothiazole
Based on 1 Customer Validation
2,4-Dibromothiazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 4175-77-3
- Formula: C3HBr2NS
- Molecular Weight:242.92
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-W001223
2-Bromothiazole
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HY-W015695
4-Methyl-5-thiazoleethanol
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HY-69360
2,5-Dibromothiazole
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HY-W012634
Benzothiazole
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HY-W015695R
4-Methyl-5-thiazoleethanol (Standard)
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HY-Y0045
2-Acetylthiazole
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HY-W002255
2,4-Dimethylthiazole-5-carboxylic acid
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HY-59320
4-Thiazolecarboxylic acid
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HY-WAA0093
2-Amino-5-methylthiazole
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HY-WAA0093R
2-Amino-5-methylthiazole (Standard)
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HY-W012634R
Benzothiazole (Standard)
Biological Activity
2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4175-77-3
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Appearance Solid
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Molecular Weight 242.92
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Formula C3HBr2NS
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Color White to light brown
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SMILES
BrC1=NC(Br)=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (823.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (20.58 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (244 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1166 mL | 20.5829 mL | 41.1658 mL | 102.9145 mL |
| 5 mM | 0.8233 mL | 4.1166 mL | 8.2332 mL | 20.5829 mL | |
| 10 mM | 0.4117 mL | 2.0583 mL | 4.1166 mL | 10.2915 mL | |
| 15 mM | 0.2744 mL | 1.3722 mL | 2.7444 mL | 6.8610 mL | |
| 20 mM | 0.2058 mL | 1.0291 mL | 2.0583 mL | 5.1457 mL | |
| 25 mM | 0.1647 mL | 0.8233 mL | 1.6466 mL | 4.1166 mL | |
| 30 mM | 0.1372 mL | 0.6861 mL | 1.3722 mL | 3.4305 mL | |
| 40 mM | 0.1029 mL | 0.5146 mL | 1.0291 mL | 2.5729 mL | |
| 50 mM | 0.0823 mL | 0.4117 mL | 0.8233 mL | 2.0583 mL | |
| 60 mM | 0.0686 mL | 0.3430 mL | 0.6861 mL | 1.7152 mL | |
| 80 mM | 0.0515 mL | 0.2573 mL | 0.5146 mL | 1.2864 mL | |
| 100 mM | 0.0412 mL | 0.2058 mL | 0.4117 mL | 1.0291 mL |
2,4-Dibromothiazole Related Classifications
HY-59304 Related Classifications
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