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Cat. No.: HY-143456

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Anti-inflammatory agent 18

Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC₅₀ of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.

For research use only. We do not sell to patients.

CAS No.: 2873386-66-2
Formula: C₃₀H₅₀O₆
Molecular Weight:506.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anti-inflammatory agent 18 Chemical Structure

CAS No.: 2873386-66-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 15.94 μM (NO)^[1]

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	15.94 μM Compound: 3b	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 34800877]

Chemical Information

CAS No. 2873386-66-2
Molecular Weight 506.71
Formula C₃₀H₅₀O₆
SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])CC(C)([C@@H]([C@H]4O)O)C)C)C)([H])[C@](C)([C@](CC1)([H])[C@](C)(O)CO)CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Y, et al. Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628. Bioorg Med Chem. 2021 Dec 15;52:116494. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Anti-inflammatory agent 18

All NO Synthase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anti-inflammatory agent 18 Related Classifications

HY-143456 Related Classifications