IFIH1 - interferon induced with helicase C domain 1 Gene

Also Known as AGS7; Hlcd; MDA5; IMD95; MDA-5; RLR-2; IDDM19; SGMRT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64135

About IFIH1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,267,074-162,318,684 (from NCBI)

This gene has 8 transcripts (splice variants), 231 orthologues, 2 paralogues and is associated with 8 phenotypes. Ubiquitous expression in spleen (RPKM 10.9), appendix (RPKM 9.9) and 25 other tissues.

Summary

IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various Other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to Infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria Infection. In addition to its protective role in Antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]

IFIH1 Products (1)

mRNA	Protein	Name
NM_022168.4	NP_071451.2	interferon-induced helicase C domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	33727702	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19656871	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	23090998	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22160685	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	21217758	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16127453	GOA
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	19881509	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	19656871	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19380577	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in MDA-5 signaling pathway	IDA IDA: Inferred from direct assay	17600090	GOA
involved in MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	19211564	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	28146100	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	33727702	GOA
involved in positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	19656871	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	17600090	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19656871	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	21156324	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	33727702	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	11805321	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	33727702	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	33727702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIH1 Protein Structure

CARD

ResIII

Helicase_C

RIG-I_C-RD

0
200
400
600
800
1025 a.a.

Protein Preferred Names	Protein Names
interferon-induced helicase C domain-containing protein 1	CADM-140 autoantigen

IFIH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFIH1	Q9BYX4	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	17600090
Intra	IFIH1	Q9BYX4	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	19416887
Cross	IFIH1	Q9BYX4	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Anti Bait CoIP	33727702
Cross	IFIH1	Q9BYX4	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Anti Tag CoIP	33727702
Intra	IFIH1	Q9BYX4	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	17600090
Cross	IFIH1	Q9BYX4	P/V	measles virus	P0C774	Anti Tag CoIP	33727702
Cross	IFIH1	Q9BYX4	P/V	measles virus	P0C774	Anti Tag CoIP	23328395
Intra	IFIH1	Q9BYX4	TKFC	Homo sapiens	Q3LXA3	Y2H	17600090
Intra	IFIH1	Q9BYX4	TKFC	Homo sapiens	Q3LXA3	Anti Bait CoIP	17600090
Intra	IFIH1	Q9BYX4	TKFC	Homo sapiens	Q3LXA3	Anti Tag CoIP	17600090
Intra	IFIH1	Q9BYX4	ISG15	Homo sapiens	P05161	Anti Tag CoIP	33727702
Intra	IFIH1	Q9BYX4	MAVS	Homo sapiens	Q7Z434	Confocal	22623778
Intra	IFIH1	Q9BYX4	IFIH1	Homo sapiens	Q9BYX4	TEM	22160685
Intra	IFIH1	Q9BYX4	ISG15	Homo sapiens	P05161	Pull Down	33727702
Intra	IFIH1	Q9BYX4	IFIH1	Homo sapiens	Q9BYX4	Comig Non-Denat Gel	25865883
Intra	IFIH1	Q9BYX4	IFIH1	Homo sapiens	Q9BYX4	GMS	22160685
Intra	IFIH1	Q9BYX4	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	22301138
Intra	IFIH1	Q9BYX4	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422
Intra	IFIH1	Q9BYX4	IFIH1	Homo sapiens	Q9BYX4	EMSA	22160685
Intra	IFIH1	Q9BYX4	ISG15	Homo sapiens	P05161	Anti Bait CoIP	33727702
Intra	IFIH1	Q9BYX4	IFIH1	Homo sapiens	Q9BYX4	Light Scattering	22160685
Intra	IFIH1	Q9BYX4	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	IFIH1	Q9BYX4	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Cross	IFIH1	Q9BYX4	P/V	Simian virus 5	P11207	Anti Tag CoIP	19403670
Cross	IFIH1	Q9BYX4	US11	Human herpesvirus 1	P04487	Anti Bait CoIP	22301138
Cross	IFIH1	Q9BYX4	US11	Human herpesvirus 1	P04487	Anti Tag CoIP	22301138
Cross	IFIH1	Q9BYX4	P/V	Measles virus	Q9EMA9	Anti Tag CoIP	19403670
Cross	IFIH1	Q9BYX4	P/V	Mumps virus	P30927	Anti Tag CoIP	19403670

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFIH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71641	IFIH1 Protein, Human (His)	Q9BYX4 (K700-D1025)	≥ 95%, as determined by reducing SDS-PAGE.

IFIH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82654	MDA5 Antibody (YA2399)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Singleton-Merten Syndrome 1	SGMRT1 Singleton-Merten Syndrome, Type 1
Aicardi-Goutieres Syndrome 7	AGS7 Aicardi-Goutieres Syndrome, Type 7
Immunodeficiency 95	IMD95
Singleton-Merten Syndrome	Singleton-Merten Dysplasia Widened Medullary Cavities Of Bone, Aortic Calcification, Abnormal Dentition, And Muscular Weakness Singleton Merten Syndrome Merten-Singleton Syndrome Sm Syndrome Syndrome Of Widened Medullary Cavities Of The Metacarpals And Phalanges, Aortic Calcification And Abnormal Dentition
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Type 1 Diabetes Mellitus 19	Diabetes Mellitus, Insulin-Dependent, 19 IDDM19 T1D19 Insulin-Dependent Diabetes Mellitus 19
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Dermatomyositis	Amyopathic Dermatomyositis Dermatopolymyositis Adult Dermatomyositis Polymyositis With Skin Involvement Adult Type Dermatomyositis Petges-Clejat Syndrome
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Subacute Sclerosing Panencephalitis	SSPE Dawson Encephalitis Immunosuppressive Measles Encephalitis Subacute Sclerosing Leukoencephalitis Panencephalitis, Subacute Sclerosing Subacute Sclerosing Leukoencephalopathy Van Bogaert'S Sclerosing Leukoencephalitis Dawson Disease Subacute Inclusion Body Encephalitis Van Bogaert Disease Van Bogaert Encephalitis Measles Inclusion Body Encephalitis Mibe - [Measles Inclusion Body Encephalitis] Sspe - [Subacute Sclerosing Panencephalitis] Van Bogaert Leukoencephalitis Van Bogaert Sclerosing Leukoencephalitis Dawson Inclusion Body Encephalitis Van Bogaert Sclerosing Leukoencephalopathy Bodechtel Guttman Disease Diffuse Sclerosing Encephalitis
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Acute Interstitial Pneumonia	Acute Interstitial Pneumonitis Hamman-Rich Syndrome Accelerated Interstitial Pneumonia Aip Hamman-Rich Disease Idiopathic Pulmonary Fibrosis, Acute Fatal Form Idiopathic Pulmonary Fibrosis
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Mouth Disease	Mouth Diseases Mouth Disorders
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Psoriasis
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Diabetes Mellitus	Diabetes
Stomatitis
Immunodeficiency 15a	IMD15A
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Palmoplantar Keratoderma, Punctate Type Iii	Acrokeratoelastoidosis Of Costa Ake Punctate Palmoplantar Keratoderma Type Iii PPKP3 Keratoderma, Palmoplantar, Punctate Type 3 Punctate Palmoplantar Hyperkeratosis Type 3 Punctate Palmoplantar Keratoderma Type 3 Rare Form Of Hirschsprung'S Disease Acrokeratoelastoidosis Collagenous Plaques Of Hands And Feet Aganglionosis, Total Intestinal Collagenous Plaques Of Hand And Feet Palmoplantar Keratoderma, Punctate Type 3 Aganglionosis, Total Colonic Ntia Near-Total Intestinal Aganglionosis Tia
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Renal Pelvis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Kidney Pelvis Squamous Cell Carcinoma Of Renal Pelvis
Exanthem	Exanthema Rash Rashes
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Dyschromatosis Symmetrica Hereditaria	Dyschromatosis Symmetrica Hereditaria 1 Reticulate Acropigmentation Of Dohi DSH Dsh1 Symmetric Dyschromatosis Of The Extremities Rad Familial Reticulate Acropigmentation Of Dohi Acropigmentation Of Dohi Symmetrical Dyschromatosis Of Extremities
Torch Syndrome
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Cryptogenic Organizing Pneumonia	Bronchiolitis Obliterans Organizing Pneumonia Boop Constrictive Bronchiolitis Cryptogenic Organizing Pneumonitis Cop Bronchiolitis Obliterans Organising Pneumonia Cryptogenic Organising Pneumonia Cryptogenic Organising Pneumonitis Idiopathic Bronchiolitis Obliterans With Organising Pneumonia Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia Organizing Pneumonia Idiopathic Boop Idiopathic Bronchiolitis Obliterans Organizing Pneumonia Organized Pneumonia
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Poliomyelitis	Polio Infantile Paralysis
Muscle Tissue Disease
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Herpangina	Vesicular Pharyngitis
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Muscular Disease
Coronavirus Infectious Disease
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Integumentary System Disease
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Myopathy	Muscular Diseases Myopathies
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06559	IFIH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18521	Ifih1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25003	Ifih1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFIH1	MGD	MGI:1918836
Canis familiaris	IFIH1	VGNC	VGNC:41876
Felis catus	IFIH1	VGNC	VGNC:80243
Macaca mulatta	IFIH1	VGNC	VGNC:73419
Bos taurus	IFIH1	VGNC	VGNC:30048
Rattus norvegicus	IFIH1	RGD	RGD:1560496
Others	IFIH1	NCBI