TKFC - triokinase and FMN cyclase Gene

Also Known as DAK; NET45; TKFCD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26007

About TKFC

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,333,228-61,353,426 (from NCBI)

This gene has 21 transcripts (splice variants), 191 orthologues and is associated with 3 phenotypes. Broad expression in duodenum (RPKM 30.4), small intestine (RPKM 22.4) and 23 other tissues.

Summary

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from Other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]

TKFC Products (6)

mRNA	Protein	Name
NM_001351976.2	NP_001338905.1	triokinase/FMN cyclase isoform b
NM_001351977.2	NP_001338906.1	triokinase/FMN cyclase isoform a
NM_001351978.2	NP_001338907.1	triokinase/FMN cyclase isoform c
NM_001351979.2	NP_001338908.1	triokinase/FMN cyclase isoform d
NM_001351980.2	NP_001338909.1	triokinase/FMN cyclase isoform e
NM_015533.4	NP_056348.2	triokinase/FMN cyclase isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables FAD-AMP lyase (cyclizing) activity	IDA IDA: Inferred from direct assay	16289032	GOA
enables glycerone kinase activity	IDA IDA: Inferred from direct assay	4688871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17600090	GOA
enables triokinase activity	IDA IDA: Inferred from direct assay	4688871	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in carbohydrate metabolic process	IDA IDA: Inferred from direct assay	4688871	GOA
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	4688871	GOA
involved in negative regulation of MDA-5 signaling pathway	IDA IDA: Inferred from direct assay	17600090	GOA
involved in regulation of innate immune response	IDA IDA: Inferred from direct assay	16289032	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
triokinase/FMN cyclase	ATP-dependent dihydroxyacetone kinase

TKFC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TKFC	Q3LXA3	SDCBP	Homo sapiens	O00560	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Triokinase And Fmn Cyclase Deficiency Syndrome	TKFCD
Sengers Syndrome	Mitochondrial Dna Depletion Syndrome 10 Cardiomyopathy And Cataract Cataract And Cardiomyopathy MTDPS10 Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10 Senger Syndrome
Inherited Metabolic Disorder	Inborn Errors Of Metabolism Inborn Metabolic Disorder Inborn Metabolism Disorder Metabolic Hereditary Disorder Inborn Error Of Metabolism Metabolism, Inborn Errors
Squamous Cell Bile Duct Carcinoma	Bile Duct Squamous Cell Carcinoma
Lung Combined Type Small Cell Carcinoma	Combined Small Cell Carcinoma Of The Lung Combined Type Small Cell Carcinoma Of Lung
Microcytic Anemia	Iron-Refractory Iron Deficiency Anemia
Fructosuria, Essential	Essential Fructosuria Ketohexokinase Deficiency Fructosuria Hepatic Fructokinase Deficiency Fructokinase Deficiency FRUCT Deficiency Of Fructokinase
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14558	TKFC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20826	Tkfc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27340	Tkfc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TKFC	VGNC	VGNC:66202
Canis familiaris	TKFC	VGNC	VGNC:47390
Bos taurus	TKFC	VGNC	VGNC:56287
Macaca mulatta	TKFC	VGNC	VGNC:79441
Rattus norvegicus	TKFC	RGD	RGD:1311026
Mus musculus	TKFC	MGD	MGI:2385084
Others	TKFC	NCBI