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Cat. No.: HY-N16831

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Moracenin D

Moracenin D is a natural flavonoid.

For research use only. We do not sell to patients.

CAS No.: 78277-79-9
Formula: C₄₀H₃₈O₁₂
Molecular Weight:710.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Moracenin D Chemical Structure

CAS No.: 78277-79-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Moracenin D is a natural flavonoid.

IC₅₀ & Target^[1]

Nurr1/NR4A2

α-synuclein

In Vitro

Moracenin D (0.16-4 μM; 24 h) protects SH-SY5Y cells against dopamine-induced cell death (EC₅₀ = 3.6 μM)^[1].
Moracenin D (0.16-4 μM; 9-15 h) up-regulates nurr1 expression and down-regulates α-synuclein expression in dopamine-treated cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

0.16-4 μM
Incubation Time:

24 h
Result:

Protected SH-SY5Y cells against dopamine-induced cell death with an EC₅₀ of 3.6 ± 0.9 μM

RT-PCR^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

0.16-4 μM
Incubation Time:

9 h
Result:

Up-regulated nurr1 mRNA expression and down-regulated α-synuclein mRNA expression in a dose-dependent manner compared to the dopamine-alone group

Western Blot Analysis^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

0.16-4 μM
Incubation Time:

15 h
Result:

Increased nurr1 protein expression and decreased α-synuclein protein expression in a dose-dependent manner compared to the dopamine-alone group

Chemical Information

CAS No. 78277-79-9
Molecular Weight 710.72
Formula C₄₀H₃₈O₁₂
SMILES

OC1=CC(O)=C(C(C(CCC(C)(O)C)=C(C2=C(C=C(C=C2)O)O)O3)=O)C3=C1[C@@H]4[C@H]([C@H](C5=C(C=C(C=C5)O)O)CC(C)=C4)C(C6=C(C=C(C=C6)O)O)=O
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ham A, et al. Moracenin D from Mori Cortex radicis protects SH-SY5Y cells against dopamine-induced cell death by regulating nurr1 and α-synuclein expression. Phytother Res. 2012;26(4):620-624. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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