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Cat. No.: HY-133944

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Nitrosulfathiazole

(Synonyms: Nisulfazole; p-Nitrosulfathiazole)

Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia.

For research use only. We do not sell to patients.

CAS No.: 473-42-7
Formula: C₉H₇N₃O₄S₂
Molecular Weight:285.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nitrosulfathiazole Chemical Structure

CAS No.: 473-42-7

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Biological Activity
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Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

Nitrosulfathiazole mediates chloramphenicol-induced hematotoxicity by inhibiting DNA synthesis, causing helix destabilization, and inducing strand breakage in bone marrow stem cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 473-42-7
Molecular Weight 285.30
Formula C₉H₇N₃O₄S₂
SMILES

O=S(C1=CC=C([N+]([O-])=O)C=C1)(NC2=NC=CS2)=O
Synonyms

Nisulfazole; p-Nitrosulfathiazole
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shukla, P., & Singh, R. K. (2013). Effect of oral administration of chloramphenicol on hematological profile of male charles foster rats. Global journal of medical research pharma, drug discovery, toxicology and medicine, 13.

[2]. Holt D, et al. Chloramphenicol toxicity. Adverse Drug React Toxicol Rev. 1993 Summer;12(2):83-95. PMID: 8357947.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Nitrosulfathiazole

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Nitrosulfathiazole Related Classifications

HY-133944 Related Classifications