1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. JNJ-42253432

JNJ-42253432 

Cat. No.: HY-123481
Handling Instructions

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively.

For research use only. We do not sell to patients.

JNJ-42253432 Chemical Structure

JNJ-42253432 Chemical Structure

CAS No. : 1428327-35-8

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5 mg USD 620 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1].

In Vivo

When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.63

Formula

C28H38N4O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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JNJ-42253432
Cat. No.:
HY-123481
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