2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. JNJ-42253432

JNJ-42253432 

Cat. No.: HY-123481 Purity: 98.44%
COA Handling Instructions

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively.

For research use only. We do not sell to patients.

JNJ-42253432 Chemical Structure

JNJ-42253432 Chemical Structure

CAS No. : 1428327-35-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 682 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 682 In-stock
Solid
5 mg USD 620 In-stock
10 mg USD 980 In-stock
25 mg USD 1950 In-stock
50 mg USD 3150 In-stock
100 mg USD 4750 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1].

In Vivo

When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

446.63

Appearance

Solid

Formula

C28H38N4O
CAS No.
SMILES

O=C(NCC1(CCCCC1)N2CCN(CC2)C3=CC=CC=C3)C4=CC=CC5=C4CCN(C5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2390 mL 11.1949 mL 22.3899 mL
5 mM 0.4478 mL 2.2390 mL 4.4780 mL
10 mM 0.2239 mL 1.1195 mL 2.2390 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

JNJ-422534321428327-35-8JNJ42253432JNJ 42253432P2X ReceptorP2XRsP2X7 channelserotoninSERTInhibitorinhibitorinhibit

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