1428327-35-8
1428327-35-8
Chemical Structure
JNJ-42253432
- CAS 番号: 1428327-35-8
- Formula:C28H38N4O
- Molecular Weight:446.63
IUPAC Name: 2-methyl-N-((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide
InChIKey: DIKKTLPJDURHSW-UHFFFAOYSA-N
SMILES: O=C(NCC1(CCCCC1)N2CCN(CC2)C3=CC=CC=C3)C4=CC=CC5=C4CCN(C5)C
Biological Activity: JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1].
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JNJ-42253432 | 98.15% | JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively. | ||||||||||||||||||||
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