EGFR-IN-203
EGFR-IN-203 is a EGFR kinase domain inhibitor targeting EGFRT790M/C797S/V948R. EGFR-IN-203 stably binds to the allosteric pocket of EGFR in an inactive conformation. EGFR-IN-203 can be used in research related to cancers such as non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3105969-17-0
- Formula: C38H32N4O4
- Molecular Weight:608.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
EGFR-IN-203 (Compound 3h389) stably binds to the allosteric pocket of the EGFR kinase domain in the EGFRT790M/C797S/V948R mutant via dominant electrostatic interactions, and exhibits an extremely strong absolute binding free energy of -25.6 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3105969-17-0
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Molecular Weight 608.69
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Formula C38H32N4O4
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SMILES
COC(C1=CC2=C(NC=C2C(C3=CNC4=C3C=C(C=C4)C(OC)=O)C5=CC=C(C=C5)C6NCCC7=C6NC8=CC=CC=C87)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-203 Related Classifications
HY-181714 Related Classifications
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