PPCDC - phosphopantothenoylcysteine decarboxylase Gene

Also Known as coaC; MDS018; PPC-DC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60490

About PPCDC

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,023,590-75,050,726 (from NCBI)

This gene has 11 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 1.6), appendix (RPKM 1.5) and 25 other tissues.

Summary

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last Enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

PPCDC Products (6)

mRNA Protein Name
NM_001301101.2 NP_001288030.1 phosphopantothenoylcysteine decarboxylase isoform b
NM_001301102.2 NP_001288031.1 phosphopantothenoylcysteine decarboxylase isoform c
NM_001301103.2 NP_001288032.1 phosphopantothenoylcysteine decarboxylase isoform d
NM_001301104.2 NP_001288033.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_001301105.2 NP_001288034.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_021823.5 NP_068595.3 phosphopantothenoylcysteine decarboxylase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables FMN binding IDA
IDA: Inferred from direct assay
14501115 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
14501115 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables phosphopantothenoylcysteine decarboxylase activity EXP
EXP: Inferred from Experiment
15581364 GOA
enables phosphopantothenoylcysteine decarboxylase activity IDA
IDA: Inferred from direct assay
11923312 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in coenzyme A biosynthetic process IDA
IDA: Inferred from direct assay
11923312 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPCDC Protein Structure

Flavoprotein

Flavoprotein: Flavoprotein (19 - 149)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

phosphopantothenoylcysteine decarboxylase

PPCDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPCDC Q96CD2 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
PPCDC Q96CD2 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Array
32296183
Intra
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Prey Pooling
25416956
Intra
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Prey Pooling
32296183
Intra
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Array
31515488
Intra
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Validated Y2H
25416956
Intra
PPCDC Q96CD2 TGM7 Homo sapiens Q96PF1
Validated Y2H
32296183
Intra
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
Intra
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
Intra
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Y2H Array
25416956
Intra
PPCDC Q96CD2 PPIG Homo sapiens Q13427
Y2H Prey Pooling
25416956
Intra
PPCDC Q96CD2 PPIG Homo sapiens Q13427
Y2H Array
25416956
Intra
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Validated Y2H
32296183
Intra
PPCDC Q96CD2 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Array
25416956
Intra
PPCDC Q96CD2 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
GMS
26514574
Intra
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PPCDC Q96CD2 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
25416956
Intra
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32296183
Intra
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPCDC Proteins

Cat. No. Product Name Accession Purity
HY-P71222 PPC-DC Protein, Human (His) Q96CD2-1 (M1-S204) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71222A PPC-DC Protein, Human (His, solution) Q96CD2-1 (M1-S204) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cecum Carcinoma

  • Cecum Cancer

  • Caecum Carcinoma

  • Carcinoma Of Cecum

  • Cecal Cancer

  • Malignant Neoplasm Of Caecum

  • Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

  • Cecal Adenocarcinoma

  • Adenocarcinoma Of Cecum
Thyroid Dyshormonogenesis 6

  • TDH6

  • Genetic Defect In Thyroid Hormonogenesis 6

  • Thyroid Hormonogenesis, Genetic Defect In, 6

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6

  • Chdh6

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 6
Colon Mucinous Adenocarcinoma

  • Colonic Mucinous Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Colon
Neurodegeneration With Brain Iron Accumulation 1

  • Pantothenate Kinase-Associated Neurodegeneration

  • Pkan

  • NBIA1

  • Hallervorden-Spatz Disease

  • Hallervorden-Spatz Syndrome

  • Pigmentary Pallidal Degeneration

  • Neuroaxonal Dystrophy, Late Infantile

  • Neurodegeneration With Brain Iron Accumulation Type 1

  • Classic Pantothenate Kinase-Associated Neurodegeneration

  • Pkan Neuroaxonal Dystrophy, Juvenile-Onset

  • Brain Iron Accumulation Type I Syndrome

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation

  • Nbia1, Classic Form

  • Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form

  • Pkan, Classic Form

  • Atypical Pantothenate Kinase-Associated Neurodegeneration

  • Nbia1, Atypical Form

  • Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form

  • Pkan, Atypical Form

  • Hss

  • Pkan Neuroaxonal Dystrophy Juvenile-Onset

  • Neurodegeneration, With Brain Iron Accumulation, Type 1
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10934 PPCDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21695 Ppcdc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28213 Ppcdc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPCDC VGNC VGNC:64306
Rattus norvegicus PPCDC RGD RGD:1306267
Mus musculus PPCDC MGD MGI:1914062
Bos taurus PPCDC VGNC VGNC:33188
Macaca mulatta PPCDC VGNC VGNC:76124
Canis familiaris PPCDC VGNC VGNC:44840
Others PPCDC NCBI