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Cat. No.: HY-124070

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ISA 27

ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer).

For research use only. We do not sell to patients.

CAS No.: 1254366-73-8
Formula: C₁₉H₁₄ClN₃O₃S
Molecular Weight:399.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ISA 27 Chemical Structure

CAS No.: 1254366-73-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.44 μM Compound: 9c	Cytotoxicity against transformed human HEK293 cells after 24 to 48 hrs by MTT assay Cytotoxicity against transformed human HEK293 cells after 24 to 48 hrs by MTT assay	[PMID: 21058726]
M14	IC₅₀	0.53 μM Compound: 9c	Cytotoxicity against human M14 cells after 24 to 48 hrs by MTT assay Cytotoxicity against human M14 cells after 24 to 48 hrs by MTT assay	[PMID: 21058726]
U-373MG ATCC	IC₅₀	5.7 μM Compound: 46; ISA27	Antiproliferative activity against human U373MG cells after 48 hrs by MTS assay Antiproliferative activity against human U373MG cells after 48 hrs by MTS assay	[PMID: 30583248]
U-87MG ATCC	IC₅₀	2.5 μM Compound: 46; ISA27	Antiproliferative activity against human U87MG cells after 48 hrs by MTS assay Antiproliferative activity against human U87MG cells after 48 hrs by MTS assay	[PMID: 30583248]
U-937	IC₅₀	0.87 μM Compound: 9c	Cytotoxicity against human U937 cells after 24 to 48 hrs by MTT assay Cytotoxicity against human U937 cells after 24 to 48 hrs by MTT assay	[PMID: 21058726]

Chemical Information

CAS No. 1254366-73-8
Molecular Weight 399.85
Formula C₁₉H₁₄ClN₃O₃S
SMILES

O=C1[C@]2(C3=CC=CC=C3N1)N4[C@@](C(N(C4=O)CC5=CC=C(C=C5)Cl)=O)([H])CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sorriento D, et al. New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53. Br J Cancer. 2015 Jan 6;112(1):77-85. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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