1254366-73-8
1254366-73-8
Chemical Structure
ISA 27
- CAS No.: 1254366-73-8
- Formula:C19H14ClN3O3S
- Molecular Weight:399.85
IUPAC Name: (3R,7aR)-6-(4-chlorobenzyl)-1,7a-dihydro-5H-spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H)-trione
InChIKey: POVQHLNFAUGINO-HNAYVOBHSA-N
SMILES: O=C1[C@]2(C3=CC=CC=C3N1)N4[C@@](C(N(C4=O)CC5=CC=C(C=C5)Cl)=O)([H])CS2
Biological Activity: ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer)[1].
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ISA 27 | ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer). | |||||||||||||||||||||
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References
Keywords
