3-Nitro-L-tyrosine
Based on 1 Customer Validation
3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 621-44-3
- 分子式: C9H10N2O5
- 分子量:226.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Human Endogenous Metabolite |
3-Nitro-L-tyrosine can be found in the brain as a product of superoxide and nitric oxide, and serves as a marker for oxidative stress induced by reactive oxygen species and nitric oxide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 250-350 g, pentobarbital-anesthetized, surgically implanted with hemodynamic monitoring catheters and Doppler flow probes)[2]
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Dosage:2.5 μmol/kg
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Administration:i.v.; single bolus
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Result:Produced a significant 36% increase in baseline hindquarter vascular resistance at 120-180 min post-treatment.
Diminished the dose-dependent pressor responses to angiotensin II at 120-180 min post-treatment.
Significantly reduced the dose-dependent vasoconstrictor effects of angiotensin II in renal and mesenteric beds at 30-60 min post-treatment, with further attenuation evident at 120-180 min post-treatment.
Did not alter the minor effects of angiotensin II on hindquarter vascular resistance.
化学情報
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CAS 番号 621-44-3
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性状 Solid
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分子量 226.19
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分子式 C9H10N2O5
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Color Light yellow to yellow
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SMILES
N[C@@H](CC1=CC([N+]([O-])=O)=C(C=C1)O)C(O)=O
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別名
3-ニトロ-L-チロシン
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 4.76 mg/mL (21.04 mM; ultrasonic and adjust pH to 2 with 1 M HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (287 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Maruyama W, et al. Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):153-8. [Content Brief]
[2]. Kooy NW, et al. The peroxynitrite product 3-nitro-L-tyrosine attenuates the hemodynamic responses to angiotensin II in vivo. Eur J Pharmacol. 1996 Nov 14;315(2):165-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4211 mL | 22.1053 mL | 44.2106 mL | 110.5265 mL |
| 5 mM | 0.8842 mL | 4.4211 mL | 8.8421 mL | 22.1053 mL | |
| 10 mM | 0.4421 mL | 2.2105 mL | 4.4211 mL | 11.0527 mL | |
| 15 mM | 0.2947 mL | 1.4737 mL | 2.9474 mL | 7.3684 mL | |
| 20 mM | 0.2211 mL | 1.1053 mL | 2.2105 mL | 5.5263 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Nitro-L-tyrosine 関連分類
HY-113248 関連分類
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