7-MAD-MDCPT
Based on 1 Customer Validation
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.85%
- CAS 番号: 765871-81-6
- 分子式: C22H19N3O6
- 分子量:421.40
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
ADC Payloads アイソフォーム固有の製品をすべて表示
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生物活性
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Camptothecins |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DEL | IC50 |
0.7 nM
Compound: 88
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Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
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[PMID: 39068862] |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 765871-81-6
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性状 Solid
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分子量 421.40
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分子式 C22H19N3O6
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Color Yellow to brown
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SMILES
NCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(OCO6)=C6C=C51
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (237.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3730 mL | 11.8652 mL | 23.7304 mL | 59.3261 mL |
| 5 mM | 0.4746 mL | 2.3730 mL | 4.7461 mL | 11.8652 mL | |
| 10 mM | 0.2373 mL | 1.1865 mL | 2.3730 mL | 5.9326 mL | |
| 15 mM | 0.1582 mL | 0.7910 mL | 1.5820 mL | 3.9551 mL | |
| 20 mM | 0.1187 mL | 0.5933 mL | 1.1865 mL | 2.9663 mL | |
| 25 mM | 0.0949 mL | 0.4746 mL | 0.9492 mL | 2.3730 mL | |
| 30 mM | 0.0791 mL | 0.3955 mL | 0.7910 mL | 1.9775 mL | |
| 40 mM | 0.0593 mL | 0.2966 mL | 0.5933 mL | 1.4832 mL | |
| 50 mM | 0.0475 mL | 0.2373 mL | 0.4746 mL | 1.1865 mL | |
| 60 mM | 0.0396 mL | 0.1978 mL | 0.3955 mL | 0.9888 mL | |
| 80 mM | 0.0297 mL | 0.1483 mL | 0.2966 mL | 0.7416 mL | |
| 100 mM | 0.0237 mL | 0.1187 mL | 0.2373 mL | 0.5933 mL |
7-MAD-MDCPT 関連分類
HY-132162 関連分類
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