8-Aminoadenine
Based on 1 Customer Validation
8-Aminoadenine is an adenine receptor 1 (rAde1R) inhibitor with a Ki of 6.51 μM in rat and 0.0341 μM in human. 8-Aminoadenine inhibits isoprenaline-induced cAMP accumulation and adenine uptake in astrocytoma cells expressing rAde1R. 8-Aminoadenine serves as a lead structure for the development of adenine receptor ligands to elucidate the functions of the adenine receptor family.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.34%
- CAS 番号: 28128-33-8
- 分子式: C5H6N6
- 分子量:150.14
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
Ki：6.51 μM (adenine receptor)[1].
8-Aminoadenine (Compound 33) binds to rat cerebral cortex membrane preparations (rAde1R) with a Ki value of 6.51 μM[1].
8-Aminoadenine binds to HEK293 cell membrane preparations with a Ki value of 0.0341 μM[1].
8-Aminoadenine (500 μM; 10 min) inhibits isoprenaline (HY-B0468)-induced cAMP accumulation in 1321N1 astrocytoma cells[1].
8-Aminoadenine (100 μM; 1 min) potently inhibits [3H] adenine uptake in 1321N1 astrocytoma cells stably expressing rAde1R[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 28128-33-8
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性状 Solid
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分子量 150.14
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分子式 C5H6N6
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Color Brown to reddish brown
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SMILES
NC1=C2N=C(N)NC2=NC=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
1 M HCl : 0.5 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M HCl | 1 mM | 6.6605 mL | 33.3023 mL | 66.6045 mL | 166.5113 mL |
8-Aminoadenine 関連分類
HY-103172 関連分類
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- 8-Aminoadenine
- 28128-33-8
- P2Y Receptor
- rat brain cortical membrane preparations
- adenine receptor family
- rAde1R
- human embryonic kidney (HEK293) cell membrane preparations
- 1321N1 astrocytoma cells
- human adenine binding site
- rat adenine receptor 1
- adenine receptor ligands
- astrocytoma cells
- Inhibitor
- inhibitor
- inhibit