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8-Bromo-cAMP

(別名: 8-Br-Camp)
39 Cited Publications
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Based on 39 publication(s) in Google Scholar

8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells.

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  • 純度: 99.48%
  • CAS 番号: 23583-48-4
  • 分子式: C10H11BrN5O6P
  • 分子量:408.10
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 8-Bromo-cAMP Chemical Structure
    8-Bromo-cAMP 構造式
  • Experimental Validation Results for 8-Bromo-cAMP
  • Experimental Validation Results for 8-Bromo-cAMP
  • Experimental Validation Results for 8-Bromo-cAMP
  • Experimental Validation Results for 8-Bromo-cAMP
  • Experimental Validation Results for 8-Bromo-cAMP
CAS 番号: 23583-48-4
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  • 8-Bromo-cAMP Chemical Structure
    8-Bromo-cAMP Chemical Structure
    1/16
  • 1/16

    8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: EMBO J. 2024 Nov;43(21):5018-5036. [Abstract]

    Customer Validation
     Human ESC cell line (hESCs) was treated with 8-Bromo-cAMP sodium salt (0.5 mM; 1-8 days) plus MPA (1 μM) for different times, and western blotting assay was used to detect the expression of CDKN2A, CDKN1A, TP53 (indicator of cell senescence) and PRL.

  • 1/16

    8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Part Fibre Toxicol. 2022 Feb 17;19(1):13. [Abstract]

    Customer Validation
     Leydig cells were incubated with 0.2 mg/mL PS-MPs for 1 h and then cultured in serum-free medium in the presence of 0.1 mM 8-Bromo-cAMP sodium salt (0.1 mM) for another 24 h. The expression of StAR in cells was analyzed by western blotting.

  • 1/16

    8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2419-2432. [Abstract]

    Customer Validation
     Histopathological changes in the colon tissue sections from from Npr1−/− mice treated with 8-Bromo-cAMP sodium salt (8-Br-cGMP, 0.1 mM; i.v.; Once daily for 4 weeks) or saline (n = 4).

  • 1/16

    8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]

    Customer Validation
     8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly elevated both PKA and p-PKA levels in SiNPs-treated AC16 cells.

  • 1/16

    8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]

    Customer Validation
     8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly reduced apoptosis of AC16 cells induced by SiNPs.

  • 8-Bromo-cAMP