Lysipressin
Based on 2 publication(s) in Google Scholar
Lysipressin (Lysine vasopressin ; [Lys8]-Vasopressin ) is a neurohypophyseal nonapeptide with dual cardiovascular regulatory activities of peripheral pressor action and central hypotensive action, and it also regulates pain perception in the body. Lysipressin is an Oxytocin Receptor agonist, with a Ki value of 10.2 nM for porcine OT receptor. Lysipressin stimulates contraction of rabbit bladder smooth muscle via V1-vasopressin receptor. The central hypotensive effect of Lysipressin depends on the sympathetic tone pathway. Lysipressin dose-dependently prolongs tail-flick latency in rats, producing a stable central antinociceptive effect. Lysipressin can be used in studies related to cardiovascular regulation, hypertension and pain.
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- 純度: 99.22%
- CAS 番号: 50-57-7
- 分子式: C46H65N13O12S2
- 分子量:1056.22
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Lysipressin
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
MoreVasopressin Receptor アイソフォーム固有の製品をすべて表示
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生物活性
Lysipressin (LVP) enhances the contractile capacity of uterine muscle strips from luteal-phase and prepartum pigs in a dose-dependent manner by activating oxytocin receptors, with EC50 values of 0.392 μM and 0.223 μM, respectively; it also increases intracellular Ca2+ concentrations in prepartum porcine uterine myocytes, with an EC50 of 28.2 nM[1].
Lysipressin dose-dependently displaces [3H]oxytocin binding sites on myometrial membranes of luteal-phase pigs, with a Ki value of 10.2 nM, indicating its high affinity for oxytocin receptors[1].
Lysipressin (LVP) stimulates the contraction of bladder smooth muscle from male New Zealand white rabbits in vitro, with a mean pD2 value of 8.4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lysipressin (1.0-10.0 μ/kg; intravenous injection; single 5-second injection; intracisternal administration; single 5-second injection) loses central hypotensive activity in anesthetized dogs after Guanethidine (HY-B1251) pretreatment, whereas its peripheral vasopressor effect stays unaltered[3].
Lysipressin (150-500 ng; intracerebroventricular injection; single administration) produces significant, dose-dependent analgesic effects in the radiant heat tail-flick test[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mongrel dogs (either sex, 7-13 kg, pretreated with guanethidine 15 mg/kg i.v. 24 h prior, anaesthetized with α-chloralose)[3]
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Dosage:1.0, 10.0 mu/kg
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Administration:i.v.; single 5-second injection; intracisternal; single 5-second injection
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Result:Raised systolic and diastolic blood pressure markedly at intravenous 1.0 and 10.0 mu/kg.
Evoked bradycardia at intravenous 10.0 mu/kg.
Produced no meaningful shifts in blood pressure or heart rate at intracisternal 1.0 and 10.0 mu/kg.
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Animal Model:Mongrel dogs (either sex, 7-13 kg, anaesthetized with α-chloralose)[3]
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Dosage:0.01, 0.1, 1.0, 10, 100 mu/kg
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Administration:i.v.; single 5-second injection; intracisternal; single 5-second injection
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Result:Elevated systolic and diastolic blood pressure dose-dependently with prominent effects.
Triggered dose-dependent bradycardia with notable heart rate reduction at 10.0 and 100.0 mu/kg.
Reduced blood pressure dose-dependently at doses ≤10 mu/kg.
Slowed heart rate significantly solely at intracisternal 0.1 mu/kg.
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Animal Model:Sprague-Dawley (female, 250-350 g)[4]
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Dosage:150 ng; 500 ng (i.c.v.)
150 ng; 500 ng; 1500 ng (s.c.) -
Administration:i.c.v.; single dose; infused at 1 μl/15 sec; s.c.; single dose; 1 mL/kg
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Result:Significantly increased tail-flick latencies by 24% at 15 minutes post-injection (150 ng i.c.v.).
Significantly increased tail-flick latencies by 37-58% at 5, 10, and 15 minutes post-injection, respectively (500 ng i.c.v.).
化学情報
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CAS 番号 50-57-7
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性状 Solid
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分子量 1056.22
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分子式 C46H65N13O12S2
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Color White to off-white
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別名
Lysine vasopressin; [Lys8]-Vasopressin
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配列
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
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シーケンスの短縮
CYFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)
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Structure Classification
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Initial Source
pig
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (94.68 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (282 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yu H, et al. Lysine Vasopressin-Induced Increases in Porcine Myometrial Contractility and Intracellular Ca²⁺ Concentrations of Myometrial Cells: Involvement of Oxytocin Receptors. Biology of Reproduction, 1995, 52: 584-590. [Content Brief]
[2]. Crankshaw D, et al. [Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle. European journal of pharmacology. 1989 Dec 07;173(2-3):183-8. [Content Brief]
[3]. Tran LD, et al. Effects of lysine-vasopressin and oxytocin on central cardiovascular control. British journal of pharmacology. 1982 Sep;77(1):69-73. [Content Brief]
[4]. Kordower JH, et al. Central antinociceptive effects of lysine-vasopressin and an analogue. Peptides. 1982;3(4):613-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9468 mL | 4.7339 mL | 9.4677 mL | 23.6693 mL |
| 5 mM | 0.1894 mL | 0.9468 mL | 1.8935 mL | 4.7339 mL | |
| 10 mM | 0.0947 mL | 0.4734 mL | 0.9468 mL | 2.3669 mL | |
| 15 mM | 0.0631 mL | 0.3156 mL | 0.6312 mL | 1.5780 mL | |
| 20 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 1.1835 mL | |
| 25 mM | 0.0379 mL | 0.1894 mL | 0.3787 mL | 0.9468 mL | |
| 30 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7890 mL | |
| 40 mM | 0.0237 mL | 0.1183 mL | 0.2367 mL | 0.5917 mL | |
| 50 mM | 0.0189 mL | 0.0947 mL | 0.1894 mL | 0.4734 mL | |
| 60 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3945 mL | |
| 80 mM | 0.0118 mL | 0.0592 mL | 0.1183 mL | 0.2959 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lysipressin 関連分類
製品番号: HY-P0004
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- Lysipressin
- 50-57-7
- Lysine vasopressin
- [Lys8]-Vasopressin
- Endogenous Metabolite
- Oxytocin Receptor
- Vasopressin Receptor
- V1-vasopressin receptor
- porcine myometrial strips
- oxytocin (OT) receptor
- rabbit urinary bladder smooth muscle
- rat tail-flick latencies
- porcine myometrial membrane
- prepartum porcine myometrial cells
- porcine OT receptor
- male New Zealand white rabbit urinary bladder smooth muscle
- anesthetized dogs
- Inhibitor
- inhibitor
- inhibit