AChE-IN-120
AChE-IN-120 is a blood-brain barrier-permeable AChE inhibitor, with an IC50 of 0.91 μM and a Ki of 1.027 μM against human AChE. AChE-IN-120 exerts neuroprotective effects against oxidative damage. AChE-IN-120 can be used for the research of Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H26FN5OS
- 分子量:439.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hAChE 0.91 μM (IC50) |
hAChE 1.027 μM (Ki) |
BuChE 30.97 μM (IC50) |
AChE-IN-120 (Compound 11e) (0-8 μM) potently and selectively inhibits human acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC50 of 0.91 μM, while it only exhibits weak inhibitory activity against butyrylcholinesterase (BuChE) (IC50 = 30.97 μM)[1].
AChE-IN-120 (0.1-10 μM) exhibits low cytotoxicity against SH-SY5Y cells, and its viability inhibitory effect gradually weakens as the concentration decreases from 10 μM to 0.1 μM[1].
AChE-IN-120 (0.1-10 μM) exerts significant neuroprotective effects against H2O2-induced damage in SH-SY5Y cells at the concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 439.55
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分子式 C23H26FN5OS
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SMILES
O=C1N(CC)C2=CC(F)=CC=C2/C1=N/NC(NC3CCN(CC3)CC4=CC=CC=C4)=S
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AChE-IN-120 関連分類
HY-184791 関連分類
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