ALX-5407
ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 571147-18-7
- 分子式: C24H24FNO3
- 分子量:393.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
3 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
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[PMID: 19013063] |
| JAR | IC50 |
0.39 nM
Compound: ALX5407
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Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
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[PMID: 21975065] |
| T98G | IC50 |
4.8 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake in human T98G cells
Inhibition of [3H]glycine uptake in human T98G cells
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[PMID: 19013063] |
ALX-5407 (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1]. ALX-5407 (50 nM) shows slow dissociation kinetics in QT6-1C cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 571147-18-7
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分子量 393.45
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分子式 C24H24FNO3
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SMILES
OC(CN(C)CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
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別名
(R)-NFPS
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ALX-5407 関連分類
HY-10711 関連分類
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