Aminocandin
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp..
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- CAS 番号: 227472-48-2
- 分子式: C56H79N9O14
- 分子量:1102.28
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Fungal[1]
Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2].
Aminocandin shows half-life of 48-58 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1]
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Dosage:10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP)
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Administration:IV or IP, once daily for 11 days
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Result:Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.
化学情報
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CAS 番号 227472-48-2
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分子量 1102.28
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分子式 C56H79N9O14
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別名
HMR 3270; IP960; NXL201
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Warn PA, et al. Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents. 2010 Feb;35(2):146-51. [Content Brief]
[2]. Ghannoum MA, et al. Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis. J Antimicrob Chemother. 2007 Mar;59(3):556-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Aminocandin 関連分類
HY-P0068 関連分類
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