AMPK activator 10
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect.
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- CAS 番号: 1914176-03-6
- 分子式: C24H26ClFN4O6
- 分子量:520.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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AMPK |
AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; orally; single dose) leads to increase in the phosphorylation levels of ACC, which is a downstream target molecule of AMPK, in a dose-dependent manner[1].
AMPK activator 10 (0.5 mg/kg by iv or 1.0 mg/kg by po) has a CL of 9.02 mL/min•kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng•h/mL for rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KKAy mice[1]
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Dosage:0.3, 1, 3 mg/kg
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Administration:Orally; bid; for 21 days
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Result:Exhibited a glucose lowering effect.
The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group.
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Animal Model:Rats[1]
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Dosage:0.5 mg/kg by iv or 1.0 mg/kg by po
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Administration:IV or po
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Result:Had a CL of 9.02 mL/min•kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng•h/mL.
化学情報
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CAS 番号 1914176-03-6
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分子量 520.94
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分子式 C24H26ClFN4O6
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SMILES
COCCOC1=CC(F)=C(C(CC2)=C1)[C@H]2NC3=C(Cl)C=C(NC(O[C@H]4[C@]5([H])[C@]([C@@H](CO5)O)([H])OC4)=N6)C6=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AMPK activator 10 関連分類
HY-148684 関連分類
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