Argifin
Based on 1 Customer Validation
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 243975-37-3
- 分子式: C29H41N9O10
- 分子量:675.69
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 0.025 μM (SmChiA), 6.4 μM (SmChiB), 1.1 μM (Aspergillus fumigatus chitinase B1), 4.5 μM (human chitotriosidase)[1]
Argifin inhibits L. cuprina chitinase with IC50 values of 3.7 μM at 37 oC and 0.10 μM at 20 oC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 243975-37-3
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性状 Solid
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分子量 675.69
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分子式 C29H41N9O10
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Color White to off-white
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配列
Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})
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シーケンスの短縮
Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})
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Structure Classification
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Initial Source
Gliocladium sp
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 100 mg/mL (148.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4800 mL | 7.3998 mL | 14.7997 mL | 36.9992 mL |
| 5 mM | 0.2960 mL | 1.4800 mL | 2.9599 mL | 7.3998 mL | |
| 10 mM | 0.1480 mL | 0.7400 mL | 1.4800 mL | 3.6999 mL | |
| 15 mM | 0.0987 mL | 0.4933 mL | 0.9866 mL | 2.4666 mL | |
| 20 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
| 25 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4800 mL | |
| 30 mM | 0.0493 mL | 0.2467 mL | 0.4933 mL | 1.2333 mL | |
| 40 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL | |
| 50 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7400 mL | |
| 60 mM | 0.0247 mL | 0.1233 mL | 0.2467 mL | 0.6167 mL | |
| 80 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL | |
| 100 mM | 0.0148 mL | 0.0740 mL | 0.1480 mL | 0.3700 mL |
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