B-Raf IN 5
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2648698-30-8
- 分子式: C23H18ClF3N6O3S2
- 分子量:583.01
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.06 nM
Compound: 3b
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
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[PMID: 34958586] |
化学情報
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CAS 番号 2648698-30-8
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分子量 583.01
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分子式 C23H18ClF3N6O3S2
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SMILES
O=S(C1=CC(F)=CC=C1F)(NC2=CC(Cl)=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCOC5)=N3)=C2F)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
B-Raf IN 5 関連分類
HY-142820 関連分類
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