β-cyano-L-Alanine
Based on 1 Customer Validation
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 6232-19-5
- 分子式: C4H6N2O2
- 分子量:114.10
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult (postnatal age: 60 days) male C57BL/6J mice (25-30 g) gavage-fed with ethanol[2]
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Dosage:50 mg/kg
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Administration:Intraperitoneally
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Result:Abolished the protective effect of ethanol on cerebral I/R injury.
化学情報
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CAS 番号 6232-19-5
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性状 Solid
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分子量 114.10
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分子式 C4H6N2O2
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Color White to light yellow
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SMILES
N[C@@H](CC#N)C(O)=O
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別名
Beta-cyano-l-alanine; β-シアノ-L-アラニン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
H2O : 20 mg/mL (175.28 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (876.42 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (272 KB)
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SDS (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Piotrowski M, et al. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.J Med Chem. J Biol Chem. 2001 Jan 26;276(4):2616-21. [Content Brief]
[2]. McCarter KD, et al. Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase. Alcohol. 2019 May;76:81-89. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.7642 mL | 43.8212 mL | 87.6424 mL | 219.1061 mL |
| 5 mM | 1.7528 mL | 8.7642 mL | 17.5285 mL | 43.8212 mL | |
| 10 mM | 0.8764 mL | 4.3821 mL | 8.7642 mL | 21.9106 mL | |
| 15 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
| 20 mM | 0.4382 mL | 2.1911 mL | 4.3821 mL | 10.9553 mL | |
| 25 mM | 0.3506 mL | 1.7528 mL | 3.5057 mL | 8.7642 mL | |
| 30 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 40 mM | 0.2191 mL | 1.0955 mL | 2.1911 mL | 5.4777 mL | |
| 50 mM | 0.1753 mL | 0.8764 mL | 1.7528 mL | 4.3821 mL | |
| 60 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 80 mM | 0.1096 mL | 0.5478 mL | 1.0955 mL | 2.7388 mL | |
| 100 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
β-cyano-L-Alanine 関連分類
HY-125773 関連分類
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