Carmofur (Standard)
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 61422-45-5
- 分子式: C11H16FN3O3
- 分子量:257.26
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
化学情報
- 純度とドキュメンテーション
-
Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
-
CAS 番号 61422-45-5
-
分子量 257.26
-
分子式 C11H16FN3O3
-
SMILES
O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
-
別名
HCFU (Standard)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Jin Z, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 Jun;27(6):529-532. [Content Brief]
[2]. Realini N, Solorzano C, Pagliuca C, et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity[J]. Scientific reports, 2013, 3(1): 1035. [Content Brief]
[3]. Wu K, et al. A new use for an old drug: carmofur attenuates lipopolysaccharide (LPS)-induced acute lung injury via inhibition of FAAH and NAAA activities[J]. Frontiers in pharmacology, 2019, 10: 818. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Carmofur (Standard) 関連分類
HY-B0182R 関連分類
Powered by Bioz
- Carmofur (Standard)
- 61422-45-5
- HCFU (Standard)
- Reference Standards
- Nucleoside Antimetabolite/Analog
- SARS-CoV
- Virus Protease
- FAAH
- Ceramidase
- Glutathione Peroxidase
- Inflammation
- rectal cancer
- tumor
- anti-cancer
- anti-inflammatory
- COVID-19
- SARS-CoV-2
- acute lung injury (ALI)
- SW403
- Vero E6
- HEK293
- Raw264.7
- Swiss Webster
- C57BL/6J
- Inhibitor
- inhibitor
- inhibit