Chem-0199
Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C13H18N2O2
- 分子量:234.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Chem-0199 inhibits the binding of AEBP1 to CKAP4 in human/mouse cancer-associated fibroblasts (hCAFs/mCAFs)[1].
Chem-0199 (10-100 μM) inhibits Akt phosphorylation (p-Akt) and downregulates PD-L1 expression in mCAFs[1].
Chem-0199 (10-100 μM, 48 h) significantly increases the proportion of IFN-γ+ and TNF-α+CD8+ T cells and restores T cell cytotoxicity in mouse splenic T cells[1].
Chem-0199 (1-20 μM, 72 h) shows no significant inhibitory effect on the proliferation of multiple tumor cells (MC38, CT26, B16-F10)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT C57BL/6 mice with MC38 tumor [1]
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Dosage:3, 10 and 30 mg/kg
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Administration:Intraperitoneally injection
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Result:Reduced tumor volume.
Further enhanced tumor inhibition and prolonged mouse survival combined with anti-CTLA-4 antibody.
Increased the proportion of IFN-γ+ and TNF-α+CD8+ T cells.
Showed no abnormalities in blood routine (WBC, RBC, Hb, PLT) or H&E staining of heart, liver, lung, kidney, and intestine tissues.
化学情報
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分子量 234.29
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分子式 C13H18N2O2
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SMILES
CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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