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製品番号: HY-182033

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ClpP agonist 1

ClpP agonist 1 is a Staphylococcus aureus ClpP (SaClpP) agonist with an EC₅₀ of 1.44 μM, K_d values of 2.95 μM (isothermal titration calorimetry) and 18 μM (bio-layer interferometry), and a low drug resistance frequency. ClpP agonist 1 reduces bacterial load, shrinks infected area and improves histopathological outcomes in a mouse skin infection model. ClpP agonist 1 can be used for the research of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) skin infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 2761081-10-9
分子式: C₂₄H₂₁F₅N₄O
分子量:476.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ClpP agonist 1 構造式

CAS 番号: 2761081-10-9

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生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

ClpP agonist 1 (Compound Z1) (0.06-128 μg/mL; 18 h) exhibits potent antibacterial activity against MRSA ATCC 33591 with an MIC of 0.5 μg/mL, and this activity is dependent on the presence of SaClpP^[1].
ClpP agonist 1 (72 h) exhibits cytotoxicity against HepG2 cells, with an IC₅₀ of 3.10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-t	MRT_0-t	T_1/2	T_max	CL	C_max	Bioavailability
Mice^[1]	5 mg/kg	i.v.	1955.2 ng·h/mL	1.09 h	0.81 h	/	2.55 L/h/kg	1982.5 ng/mL	/
Mice^[1]	10 mg/kg	p.o.	1310.5 ng·h/mL	2.29 h	1.92 h	0.75 h	7.30 L/h/kg	432 ng/mL	33.5 %

体内実験

ClpP agonist 1 (Compound Z1) (2.5-10 mg/kg; s.c.; daily; 3 consecutive days) exhibits significant, dose-dependent therapeutic effects against MRSA skin infection in BALB/c mice, reducing lesion size, bacterial burden, and histopathological tissue damage with a favorable safety profile at tested doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 6-8 weeks old, 18-20 g, SPF grade)^[1]
Dosage:

2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration:

s.c.; daily; 3 consecutive days
Result:

Showed no statistically significant differences in body weight compared to the vehicle group, with no compound-related adverse effects noted.
Reduced lesion size from baseline significantly in a dose-dependent manner.
Decreased MRSA load in skin tissues remarkably compared to the vehicle group, with the 10 mg/kg dose group showing the most pronounced reduction.
Markedly alleviated tissue damage, including reduced epidermal necrosis, dermal thickening, and inflammatory cell infiltration, while preserving normal histological architecture.

化学情報

CAS 番号 2761081-10-9
分子量 476.44
分子式 C₂₄H₂₁F₅N₄O
SMILES

O=C1C2=C(N3CCN=C3N1CC4=CC=C(C=C4)C(F)(F)F)CCN(C2)CC5=CC(F)=CC(F)=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Liu Y, et al. Discovery and characterization of Z1: an imipridone-based ClpP agonist with potent anti-staphylococcal activity. Bioorg Chem. 2026;173:109685. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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