DC-5163
Based on 1 publication(s) in Google Scholar
DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC50 of 176.3 nM and a Kd of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.30%
- CAS 番号: 897771-47-0
- 分子式: C18H20ClN3OS
- 分子量:361.89
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Glycolysis Compound Library
HY-L058
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Anti-Cancer Metabolism Compound Library
HY-L083
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Glucose Metabolism Compound Library
HY-L092
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Extracellular Vesicles (EVs) Compound Library
HY-L168
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
MedChemExpress（MCE）の使用を引用している文献 DC-5163
More
生物活性
IC50: 176.3 nM (Glyceraldehyde-3-phosphate dehydrogenase (GAPDH))[1]
Kd: 3.192 μM (GAPDH)[1]
DC-5163 (100 μM; 48 hours; MDA-MB-231 cells) treatment clearly induces the apoptosis of MDA-MB-231 cells. DC-5163 also significantly reduces glucose uptake, lactate production, and 18F-FDG uptake rate compared to controls in MDA-MB-231cells[1].
DC-5163 treatment at 25 μM inhibits GAPDH activity in BT-549 cells, MCF7 cells, HCT116 cells, MDA-MB-231 cells and A549 cells after 48 hours[1].
DC-5163 inhibits MDA-MB-231 cell proliferation with an IC50 of 99.22 μM at 48 hours and 52.09 μM at 72 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:100 μM
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Incubation Time:48 hours
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Result:Clearly induced the apoptosis of MDA-MB-231 cells.
化学情報
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CAS 番号 897771-47-0
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性状 Solid
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分子量 361.89
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分子式 C18H20ClN3OS
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Color White to off-white
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SMILES
S=C(N1CCN(CC2=CC=CC=C2)C1)NC3=CC=C(OC)C(Cl)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Cell Int
The therapeutic effect of a novel GAPDH inhibitor in mouse model of breast cancer and efficacy monitoring by molecular imaging. [Abstract]2024 May 29;24(1):188. PMID: 38811918
溶剤 & 溶解度
DMSO : 300 mg/mL (828.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7633 mL | 13.8164 mL | 27.6327 mL | 69.0818 mL |
| 5 mM | 0.5527 mL | 2.7633 mL | 5.5265 mL | 13.8164 mL | |
| 10 mM | 0.2763 mL | 1.3816 mL | 2.7633 mL | 6.9082 mL | |
| 15 mM | 0.1842 mL | 0.9211 mL | 1.8422 mL | 4.6055 mL | |
| 20 mM | 0.1382 mL | 0.6908 mL | 1.3816 mL | 3.4541 mL | |
| 25 mM | 0.1105 mL | 0.5527 mL | 1.1053 mL | 2.7633 mL | |
| 30 mM | 0.0921 mL | 0.4605 mL | 0.9211 mL | 2.3027 mL | |
| 40 mM | 0.0691 mL | 0.3454 mL | 0.6908 mL | 1.7270 mL | |
| 50 mM | 0.0553 mL | 0.2763 mL | 0.5527 mL | 1.3816 mL | |
| 60 mM | 0.0461 mL | 0.2303 mL | 0.4605 mL | 1.1514 mL | |
| 80 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8635 mL | |
| 100 mM | 0.0276 mL | 0.1382 mL | 0.2763 mL | 0.6908 mL |
DC-5163 関連分類
HY-43643 関連分類
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